2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. CPD-002

CPD-002 血管内皮生长因子受体 2 (VEGFR 2) 的抑制剂，通过抑制 VEGFR2/PI3K/AKT 信号通路来抑制血管生成。CPD-002 具有抗炎活性，可减轻类风湿性关节炎。

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CPD-002 Chemical Structure

CPD-002 Chemical Structure

CAS No. : 2617376-08-4

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CPD-002 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CPD-002 is an inhibitor for vascular endothelial growth factor receptor 2 (VEGFR 2), that inhibits angiogenesis through inhibition of VEGFR2/PI3K/AKT signaling pathway. CPD-002 exhibits anti-inflammatory activity and attenuates rheumatoid arthritis[1].

体外研究
(In Vitro)

CPD-002 (0-64 μM，24-48 h) 对 HUVEC 和 MH7A 细胞具有剂量依赖性的细胞毒性[1]。
CPD-002 (0-8 μM，24 h) 通过抑制 F-肌动蛋白表达以及对 MH7A 细胞释放的趋化剂的趋化反应，抑制 VEGF 诱导的 HUVEC 细胞迁移和侵袭[1]。
CPD-002 (0-8 μM) 通过抑制 TNF-α、IL-1β、IL-6、IL-8、MMP2 和 MMP9 等炎症介质发挥抗炎活性，从而抑制滑膜血管生成[1]。
CPD-002 (0-8 μM，9 天) 在离体大鼠主动脉环测定中，抑制 HUVEC 管形成和主动脉环芽形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CPD-002 相关抗体:

Cell Viability Assay[1]

Cell Line: HUVECs and MH7A
Concentration: 0-64 μM
Incubation Time: 24-48 h
Result: Inhibited cell viability in a dose-dependent manner.

Cell Migration Assay [1]

Cell Line: HUVECs
Concentration: 0-8 μM
Incubation Time: 24 h
Result: Inhibited HUVECs migration in a dose-dependent manner.
体内研究
(In Vivo)

CPD-002 (15-60 mg/kg，腹腔注射，每天一次共 14 天) 在佐剂诱导的关节炎大鼠模型中表现出抗关节炎和抗血管生成活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: adjuvant-induced arthritis (AIA) Sprague Dawley rats models[1]
Dosage: 15-60 mg/kg
Administration: i.p., once daily for 14 days
Result: Ameliorated paw swelling, joint damage, and synovial angiogenesis.
分子量

340.40

Formula

C17H16N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CPD-002 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPD-0022617376-08-4CPD002CPD 002VEGFRVascular endothelial growth factor receptorrheumatoid arthritissynovial angiogenesisHUVECRA FLSMH7ASprague Dawley ratsInhibitorinhibitorinhibit

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产品名称：
CPD-002
目录号：
HY-163533
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