2. PI3K/Akt/mTOR
  3. Akt PI3K
  4. Antitumor agent-86

Antitumor agent-86 (compound 5a) 抑制 MCF-7 乳腺癌细胞的 IC50 值为 2.62 µM。Antitumor agent-86 诱导细胞凋亡和细胞周期阻滞，并通过靶向 RAS/PI3K/Akt/JNK 信号级联显示抗肿瘤活性。

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Antitumor agent-86 Chemical Structure

Antitumor agent-86 Chemical Structure

CAS No. : 2907704-65-6

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Antitumor agent-86 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-86 (compound 5a) inhibits MCF-7 breast cancer cells with an IC50 value of 2.62 µM. Antitumor agent-86 induces cell apoptosis and cell cycle arrest, and shows antineoplastic activity by targeting RAS/PI3K/Akt/JNK signaling cascades[1].

体外研究
(In Vitro)

Antitumor agent-86 (0-200 μM；48 h) 剂量依赖性地抑制 MCF-7，MDA-MB-231，Caco-2 和 PANC-1 癌细胞的增殖，IC50 值分别为 2.617、6.778、14.8 和 23.58 μM[1]。
Antitumor agent-86 (2.62 μM；48 h) 诱导细胞凋亡、细胞周期阻滞，降低 MCF-7 细胞的 p-RAS 蛋白水平、PI3K 和 Akt 的 mRNA 转录水平和 p-JNK 蛋白的表达[1]。
Antitumor agent-86 (2.62 μM；48 h) 上调 p21 基因的表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-86 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231, Caco-2 and PANC-1 cell lines
Concentration: 0-200 μM
Incubation Time: 48 hours
Result: Dose-dependently suppressed cell proliferation of human cancer cell lines.

Western Blot Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 2.62 μM
Incubation Time: 48 hours
Result: Decreased levels of p-JNK and p-RAS in MCF-7 cells.

Apoptosis Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 2.62 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis with morphological changess such as cell rounding and shrinkage with decreased cell number detachment and cytoplasmic condensation.
分子量

513.65

Formula

C29H31N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-86 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-862907704-65-6Antitumor agent86Antitumor agent 86AktPI3KPKBProtein kinase BPhosphoinositide 3-kinaseantitumorcell cycle arrestapoptosisRASJNKInhibitorinhibitorinhibit

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