2. Anti-infection Apoptosis PI3K/Akt/mTOR Immunology/Inflammation
  3. Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related
  4. Beauvericin

Beauvericin  (Synonyms: 白僵菌素)

目录号: HY-N6739 纯度: 99.83%
COA 产品使用指南 技术支持

Beauvericin 是一种环六肽镰刀菌毒素，具有杀虫、抗菌、抗癌、抗病毒和细胞毒活性。Beauvericin 通过产生 DNA 断裂、染色体畸变和微核，造成细胞的遗传毒性，并抑制 PI3K/AKT 通路诱导细胞凋亡 (apoptosis)，从而抑制 HCC 的生长。此外，Beauvericin 通过抑制淋巴细胞增殖和干扰人单核细胞向巨噬细胞的分化过程，来影响免疫功能。

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Beauvericin Chemical Structure

Beauvericin Chemical Structure

CAS No. : 26048-05-5

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5 mg ￥1900
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10 mg ￥2945
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Other Forms of Beauvericin:

Beauvericin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages[1][2][3][4][5][6][7][8][9].

IC50 & Target

ACAT

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
1 μM
Compound: 12
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
[PMID: 36288556]
Huh-7 IC50
4.3 μM
Compound: 12
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
[PMID: 36288556]
体外研究
(In Vitro)

Beauvericin (0-20 μM；12、24 和 36 h) 对 H22 肝癌细胞具有较强的抗增殖活性并促进 H22 肝癌细胞凋亡[5]。
Beauvericin (50 μM; 72 h) 诱导火鸡外周单核细胞发生凋亡[6]。
Beauvericin (0.3-100 µM) 以浓度依赖性的方式可逆地抑制 NG108-15 神经元细胞中 L 型电压依赖性 Ca2+ 电流 (ICa,L)，IC50 值为 4 µM[7]。
Beauvericin 对未成熟树突状细胞、成熟树突状细胞和巨噬细胞的 IC50 分别为 1.0 µM、2.9 µM 和 2.5 µM[8]。
Beauvericin (1.6 和 2.4 µM；2 d) 使成熟过程中的树突状细胞 CCR7 表达降低，IL-10 分泌增加[8]。
Beauvericin 是大鼠肝微粒体中 CYP3A1/2 的有效抑制剂 (IC50=1.3 µM)[9]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Beauvericin 相关抗体:

Cell Viability Assay[5]

Cell Line: H22 liver cancer cells
Concentration: 0, 1, 3, 5,10,15 and 20 µM
Incubation Time: 12、24 and 36 h
Result: Inhibited the growth of H22 cells in a dose-dependent manner.

Western Blot Analysis[5]

Cell Line: H22 liver cancer cells
Concentration: 0, 1, 3, 5,10,15 and 20 µM
Incubation Time: 12、24 and 36 h
Result: Upregulated the Bax/Bcl-2 ratio and the levels of cleaved caspase-9 and cleaved caspase-3, and downregulated the p-PI3K/PI3K ratio and p-AKT/AKT ratio.
体内研究
(In Vivo)

Beauvericin (5 mg/kg；i.p.；完成第一个给药周期后，观察两天后，继续第二个给药周期) 使同种异体移植模型小鼠中肿瘤体积减小和坏死增加[3]。
Beauvericin (3、5、7 mg/kg；i.p.；每周一次持续三周) 能显著抑制 H22 异体移植模型小鼠的生长，同时升高小鼠体内 TNF-α 和 IL-2 的水平[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice injected subcutaneously with mouse CT-26 colon cancer cells on the right side[3]
Dosage: 5 mg/kg
Administration: ntraperitoneal injection (i.p.)；The drug was administered on the third day after the injection of colon cancer cells and continued once a day for five days, then stopped for two days of observation, and continued on the tenth day after the injection of colon cancer cells, and continued once a day for four days.
Result: Reduced the average tumor volume by 52.8 % and the average tumor weight by 60 %.
Animal Model: Human cervical cancer KB-3-1 xenograft mouse model[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)； The drug was administered once a day starting on the fifth day after cervical cancer injection for five days, followed by two days of observation. The drug was administered once a day starting on the twelfth day after cervical cancer cell injection for four days.
Result: Reduced the average tumor volume by 31.3 % and the average tumor weight by 31.2 %.
分子量

783.95

Formula

C45H57N3O9
CAS 号
性状

固体

颜色

White to off-white

中文名称

白僵菌素
结构分类
初始来源

Fusarium proliferatum,F. semitectum, and F. subglutinans
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (127.56 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.2756 mL 6.3780 mL 12.7559 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.95%

COA (299 KB) HNMR (299 KB) LCMS (87 KB)

产品使用指南 (1538 KB)
参考文献

Beauvericin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2756 mL 6.3780 mL 12.7559 mL 31.8898 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL 6.3780 mL
10 mM 0.1276 mL 0.6378 mL 1.2756 mL 3.1890 mL
15 mM 0.0850 mL 0.4252 mL 0.8504 mL 2.1260 mL
20 mM 0.0638 mL 0.3189 mL 0.6378 mL 1.5945 mL
25 mM 0.0510 mL 0.2551 mL 0.5102 mL 1.2756 mL
30 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0630 mL
40 mM 0.0319 mL 0.1594 mL 0.3189 mL 0.7972 mL
50 mM 0.0255 mL 0.1276 mL 0.2551 mL 0.6378 mL
60 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5315 mL
80 mM 0.0159 mL 0.0797 mL 0.1594 mL 0.3986 mL
100 mM 0.0128 mL 0.0638 mL 0.1276 mL 0.3189 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Beauvericin26048-05-5白僵菌素BacterialApoptosisFungalPI3KAktTNF ReceptorInterleukin RelatedPhosphoinositide 3-kinasePKBProtein kinase BTumor Necrosis Factor ReceptorTNFRILInhibitorinhibitorinhibit

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