2. 天然产物
  3. 植物 生物碱
  4. 苦木科 吡啶类生物碱
  5. 苦木
  6. 1-Formyl-beta-carboline

1-Formyl-beta-carboline  (Synonyms: 苦木碱C)

目录号: HY-W130965
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摩尔计算器

1-Formyl-beta-carboline是一种生物碱，具有抑制新城疫病毒（NDV）的活性。1-Formyl-beta-carboline能够以10 μM以内的IC50值有效抑制不同基因型的NDV，其抑制率在20 μM的浓度下超过90%。1-Formyl-beta-carboline主要通过抑制NDV生命周期中的吸附和进入过程发挥作用。1-Formyl-beta-carboline被鉴定为新型HN抑制剂，能够直接与NDV HN蛋白相互作用，影响NDV的吸附。1-Formyl-beta-carboline还通过抑制PI3K/Akt信号通路而非ERK通路来抑制NDV的进入。

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1-Formyl-beta-carboline Chemical Structure

1-Formyl-beta-carboline Chemical Structure

CAS No. : 20127-63-3

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规格 价格 是否有货
1 mg ￥798
询问价格 & 货期
5 mg ￥1883
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10 mg ￥2765
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25 mg ￥4165
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50 mg ￥5845
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100 mg 现货 询问价格 & 货期

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1-Formyl-beta-carboline 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1].

分子量

196.20

Formula

C12H8N2O
CAS 号
性状

固体

中文名称

苦木碱C
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

1-Formyl-beta-carboline 相关分类

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Keywords:

1-Formyl-beta-carboline20127-63-3苦木碱COthersInhibitorinhibitorinhibit

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