2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species Apoptosis
  4. Chicoric acid

Chicoric acid  (Synonyms: 菊苣酸; Cichoric acid; Dicaffeoyltartaric acid)

目录号: HY-N0457 纯度: 99.95%
COA 产品使用指南

摩尔计算器

Chicoric acid (Cichoric acid) 是一种口服有效的二咖啡基酒石酸，可以诱导活性氧 (ROS) 的产生。Chicoric acid 抑制细胞活力，并通过 ROS 介导的 PI3K/Akt 和 MAPK 信号通路诱导 3T3-L1 前脂肪细胞中的线粒体依赖性细胞凋亡。Chicoric acid 增加葡萄糖摄取，改善胰岛素抵抗，并减轻氨基葡萄糖诱导的炎症。Chicoric acid 具有抗糖尿病和抗氧化、抗炎作用。

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Chicoric acid Chemical Structure

Chicoric acid Chemical Structure

CAS No. : 6537-80-0

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5 mg ￥371
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10 mg ￥600
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25 mg ￥1350
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50 mg ￥2400
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100 mg ￥3360
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Other Forms of Chicoric acid:

Chicoric acid 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3].

体外研究
(In Vitro)

Chicoric acid (Cichoric acid；10 -200 μM；持续 24、48 和 72 小时) 导致细胞活力呈剂量和时间依赖性降低[1]。
Chicoric acid (100 μM；48 h) 通过 caspase-3 依赖性途径诱导细胞凋亡[1]。
Chicoric acid (100 μM；48 h) 降低 p-Akt 的蛋白质水平[1]。
Chicoric acid (25、50、100 μM；持续 24 小时) 以剂量依赖性方式显著改善葡萄糖摄取，并且 Chicoric acid 进一步增强胰岛素诱导的 (100 nM；30 分钟) 葡萄糖摄取达 57.7% HepG2细胞[2]。
Chicoric acid (100 μM；24 小时) 通过激活 HepG2 细胞中的 PI3K/Akt 通路恢复葡萄糖胺诱导的 GLUT2 易位损伤[2]。
Chicoric acid (100 μM) 对 HepG2 细胞活力没有影响[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chicoric acid 相关抗体:

Cell Viability Assay[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 10-200 μM
Incubation Time: 24, 48, and 72 hours
Result: Had no effect on the viability of 3T3-L1 preadipocytes with 10-50 μM for 24 h, but significantly decreased cell viability with 100 μM and 200 μM.

Apoptosis Analysis[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 100 μM
Incubation Time: 48 hours
Result: Demonstrated typical characteristics of apoptosis such as cell shrinkage, chromatin condensation, and the increased permeability of cell membranes after DAPI and AO/EB staining.

Western Blot Analysis[1]

Cell Line: 3T3-L1 preadipocytes
Concentration: 100 μM
Incubation Time: 48 hours
Result: Decreased the protein level of p-Akt in a dose- and time-dependent manner.
The protein level of total Akt was not affected
体内研究
(In Vivo)

Chicoric acid（Chicoric acid；60 mg/kg/天；饮水 4 周）可抑制糖尿病小鼠的胰腺细胞凋亡并调整胰岛功能，导致使用链脲佐菌素（STZ；5 0 mg/kg；腹膜内；连续 5 天）的 C57BL/6J 小鼠胰岛素生成和分泌增加[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)[3]
Dosage: 60 mg/kg
Administration: Drinking water; daily; for 4 weeks
Result: Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion.
Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses.
Showed a remarkable increase in body weight starting at week 7.
分子量

474.37

Formula

C22H18O12
CAS 号
性状

固体

颜色

White to yellow

中文名称

菊苣酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.95%

COA (168 KB) LCMS (264 KB)

产品使用指南 (1538 KB)
参考文献

Chicoric acid 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Chicoric acid6537-80-0Cichoric acid Dicaffeoyltartaric acid菊苣酸Reactive Oxygen SpeciesApoptosisglucose uptakeinsulin resistanceglucosaminePI3K/AktMAPKantidiabeticantioxidantanti-inflammatoryROSmitochondriap-AktInhibitorinhibitorinhibit

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