2. PI3K/Akt/mTOR Apoptosis
  3. PI3K Apoptosis
  4. Ramentaceone

Ramentaceone  (Synonyms: 7-Methyljuglon)

目录号: HY-121684
产品使用指南

摩尔计算器

Ramentaceone (7-Methyljuglon) 是一种可从 Drosera sp. 提取得到的萘醌，可抑制 PI3K 活性。Ramentaceone (7-Methyljuglon) 可降低 PI3K 蛋白表达，并抑制 Akt 的磷酸化。Ramentaceone (7-Methyljuglon) 可诱导凋亡。

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Ramentaceone Chemical Structure

Ramentaceone Chemical Structure

CAS No. : 14787-38-3

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Ramentaceone 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
11.9 μM
Compound: 1
Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human DU145 cells assessed as cell survival after 24 hrs by XTT assay
[PMID: 25059501]
HeLa IC50
66.6 μM
Compound: 1
Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by XTT assay
[PMID: 25059501]
HL-60 IC50
8.75 μM
Compound: 1, 7-methyljuglone
Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
[PMID: 22250825]
MCF7 IC50
27.2 μM
Compound: 1
Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human MCF7 cells assessed as cell survival after 24 hrs by XTT assay
[PMID: 25059501]
NFF IC50
7.6 μM
Compound: 2
Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay
Cytotoxicity against human NFF cells assessed as reduction in cell viability after 48 hrs by resazurin dye based assay
[PMID: 33314932]
PBMC IC50
18.4 μM
Compound: 1
Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay
Cytotoxicity against human PBMC assessed as cell survival after 24 hrs by XTT assay
[PMID: 25059501]
Vero IC50
15.1 μg/mL
Compound: 6
Cytotoxicity against Vero cells after 48 hrs by XTT method
Cytotoxicity against Vero cells after 48 hrs by XTT method
[PMID: 17888665]
分子量

188.18

Formula

C11H8O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ramentaceone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ramentaceone14787-38-37-MethyljuglonPI3KApoptosisPhosphoinositide 3-kinaseAktapoptosisInhibitorinhibitorinhibit

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