2. PI3K/Akt/mTOR Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. PI3K HDAC Apoptosis
  4. Fimepinostat mesylate

Fimepinostat mesylate  (Synonyms: CUDC-907 mesylate)

目录号: HY-155890
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摩尔计算器

Fimepinostat mesylate 有效抑制 I 型 PI3K 及 I 和 II 型 HDAC 酶，作用于 PI3Kα/PI3Kβ/PI3Kδ 和 HDAC1/HDAC2/HDAC3/HDAC10 ，IC50 分别为 19/54/39 nM 和 1.7/5.0/1.8/2.8 nM。

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Fimepinostat mesylate Chemical Structure

Fimepinostat mesylate Chemical Structure

CAS No. : 1401998-36-4

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Fimepinostat mesylate 的其他形式现货产品:

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Fimepinostat mesylate 相关抗体

Top Publications Citing Use of Products

    Fimepinostat mesylate purchased from MCE. Usage Cited in: Acta Pharmacol Sin. 2019 May;40(5):677-688  [Abstract]

    Aspc-1 and Capan-1 cells are collected for Western blotting with the indicated antibodies after treatment with CUDC-907 for 48 h.

    查看 PI3K 亚型特异性产品:

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    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

    分子量

    604.66

    Formula

    C24H28N8O7S2
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Fimepinostat mesylate 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Fimepinostat1401998-36-4CUDC-907CUDC907CUDC 907PI3KHDACApoptosisPhosphoinositide 3-kinaseHistone deacetylasesInhibitorinhibitorinhibit

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