2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-53

Antitumor agent-53 是一种有效的抗癌剂。Antitumor agent-53 诱导细胞周期停滞在 G2/M 期。Antitumor agent-53 抑制 PI3K/AKT 信号通路并诱导 HGC-27 细胞凋亡 (apoptosis)。Antitumor agent-53 具有研究胃肠道肿瘤的潜力。

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Antitumor agent-53 Chemical Structure

Antitumor agent-53 Chemical Structure

CAS No. : 2757145-67-6

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Antitumor agent-53 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
7.87 μM
Compound: 6f
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34990980]
GES1 IC50
12.74 μM
Compound: 6c
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human GES1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 34774339]
GES1 IC50
3.1 μM
Compound: 6f
Antiproliferative activity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human GES1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34990980]
HepG2 IC50
> 18 μM
Compound: 6f
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34990980]
HGC-27 IC50
0.37 μM
Compound: 6f
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34990980]
HGC-27 IC50
2.5 μM
Compound: 6c
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 34774339]
HT-29 IC50
4.01 μM
Compound: 6f
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34990980]
MCF7 IC50
9.11 μM
Compound: 6f
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 34990980]
MGC-803 IC50
0.27 μM
Compound: 6c
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 34774339]
SGC-7901 IC50
1.67 μM
Compound: 6c
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 34774339]
体外研究
(In Vitro)

Antitumor agent-53 (compound 6f) (0, 0.22, 0.67, 2, 6, 18 µM; 72 h) shows anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells[1].
Antitumor agent-53 (0.15, 0.3, 0.6 µM) shows anti-proliferative activity in HGC-27 and HT-29 cells with a dose-dependent manner[1].
Antitumor agent-53 (100, 200 µM) shows a certain inhibitory activity against Topo I at 200 μM[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) induces cell cycle arrest at the G2/M phase in HGC-27, HT-29 cells[1].
Antitumor agent-53 (0.1, 0.3, 0.9, 2.7 μM; 24 h) induces the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner[1].
Antitumor agent-53 (0.15, 0.3, 0.6 μM; 24 h) inhibits the migration and invasion of HGC-27 cells in a concentration-dependent manner[1].
Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) suppresses the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-53 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells
Concentration: 0, 0.22, 0.67, 2, 6, 18 µM
Incubation Time: 72 h
Result: Showed anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 µM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells.

Cell Cycle Analysis[1]

Cell Line: HGC-27, HT-29 cells
Concentration: 0.1, 0.3, 0.9 μM
Incubation Time: 24 h
Result: Cells were arrest at the G2/M phase.

Apoptosis Analysis[1]

Cell Line: HGC-27, HT-29 cells
Concentration: 0.1, 0.3, 0.9, 2.7 μM
Incubation Time: 24 h
Result: Induced the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: HGC-27 cells
Concentration: 0.1, 0.3, 0.9 μM
Incubation Time: 24 h
Result: Suppressed the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells.
分子量

383.42

Formula

C24H18FN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-53 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-532757145-67-6Antitumor agent53Antitumor agent 53ApoptosisPI3K/AKTapoptosisHGC-27HT-29G2/Mgastrointestinalanti-tumorInhibitorinhibitorinhibit

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