2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR DNA-PK
  4. XRD-0394

XRD-0394 是一种具有口服活性的、强效且特异性的 ATM 和 DNA-PKcs 的双重抑制剂。XRD-0394 能在体外和体内治疗性电离辐射环境下显著增强肿瘤细胞杀伤作用。XRD-0394 还能在体外增强 PARP 和拓扑异构酶I抑制剂的效果。

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XRD-0394 Chemical Structure

XRD-0394 Chemical Structure

CAS No. : 2595308-10-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货
1 mg ￥3700
询问价格 & 货期
5 mg 现货 询问价格 & 货期
10 mg 现货 询问价格 & 货期

* Please select Quantity before adding items.

Customer Review

XRD-0394 相关抗体

Top Publications Citing Use of Products

查看 ATM/ATR 亚型特异性产品:

查看所有亚型
ATM ATR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XRD-0394 is a potent and specific dual inhibitor of ATM and DNA-PKcs with oral activity. XRD-0394 significantly enhances tumor cell killing in vitro and in vivo under therapeutic ionizing radiation conditions. In addition, XRD-0394 can potentiate the effects of PARP and topoisomerase I inhibitors in vitro[1].

分子量

527.61

Formula

C26H30FN5O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

XRD-0394 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XRD-03942595308-10-2XRD0394XRD 0394ATM/ATRDNA-PKAtaxia telangiectasia mutatedATM and RAD3 relatedDNA-dependent protein kinasetargeted deliverycancertumor cell killingInhibitorinhibitorinhibit

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产品名称：
XRD-0394
目录号：
HY-162472
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