2. PI3K/Akt/mTOR
  3. PI3K
  4. Pichromene

Pichromene  (Synonyms: S14161)

目录号: HY-111209
产品使用指南

摩尔计算器

Pichromene (S14161) 是一种抗癌剂和弱 PI3K 抑制剂。Pichromene 能有效抑制白血病小鼠模型中的肿瘤生长，可用于癌症的研究。

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Pichromene Chemical Structure

Pichromene Chemical Structure

CAS No. : 883046-50-2

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规格 价格 是否有货 数量
1 mg ￥1426
3 - 4 周
5 mg   询价  
10 mg   询价  

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Pichromene 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

查看所有亚型
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pichromene (S14161) is an anticancer agent and weak PI3K inhibitor. Pichromene can effectively inhibit tumor growth in leukemia mouse models and can be used in cancer research[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16 GI50
23.28 μM
Compound: 2, S14161
Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against mouse B16 cells after 24 to 72 hrs by SRB assay
[PMID: 23601711]
K562 GI50
1.24 μM
Compound: 2, S14161
Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human K562 cells after 24 to 72 hrs by SRB assay
[PMID: 23601711]
LP-1 GI50
0.57 μM
Compound: 2, S14161
Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human LP-1 cells after 24 to 72 hrs by SRB assay
[PMID: 23601711]
MDA-MB-231 GI50
8.53 μM
Compound: 2, S14161
Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
[PMID: 23601711]
Platelet IC50
3.79 μM
Compound: S14161
Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
Inhibition of collagen-induced platelet aggregation in human platelet rich plasma preincubated for 10 mins followed by collagen addition by aggregometric method
[PMID: 27996269]
U-87MG ATCC GI50
18.72 μM
Compound: 2, S14161
Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
Cytotoxicity against human U87 cells after 24 to 72 hrs by SRB assay
[PMID: 23601711]
分子量

315.30

Formula

C17H14FNO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pichromene 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pichromene883046-50-2S14161S 14161S-14161PI3KPhosphoinositide 3-kinasecancertumorleukemiaInhibitorinhibitorinhibit

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