Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis[2][4][6][7].
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry
Improved the cell viability of SH-SY5Y cells treated with 6-OHDA, reaching levels of 96.25% and 97.56% at concentrations of 50 μ g/mL and 100 μg/mL, respectively.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Rat myocardial ischemia model established by intraperitoneal injection of DOX (2.5 mg/kg) (HY-15142A) 6 times every other day [1].
Dosage:
25, 50, 100 mg/kg
Administration:
Oral gavage (p.o.); once daily; 2 weeks
Result:
Reduced the production of cardiac antioxidant enzymes, pro-inflammatory cytokines, and lipid biomarkers, and increased the expression of anti-inflammatory cytokines.
Inhibited Rotenone (HY-B1756) induced reactive oxygen species production, lipid peroxidation, and enhanced Nrf2 expression, catalase, glutathione peroxidase, and superoxide dismutase levels in the brain.
Animal Model:
A mouse model of rhabdomyolysis induced by a single intramuscular injection of 50% glycerol at a dose of 10 ml/kg [5].
Dosage:
50, 100 mg/kg
Administration:
Oral gavage (p.o.); once daily; 4 days
Result:
Reduced KIM-1 mRNA and myoglobin levels, as well as cleaved caspase-3 and BAX protein levels in renal tissue.
Animal Model:
NSCLC nude mouse model established by subcutaneous injection of NCI-H1299 cells into the posterior abdomen of 7-week-old BALB/c (nu/nu) nude mice[6].
Dosage:
12.5, 25, 50 mg/kg
Administration:
Intraperitoneal injection (i.p.); once daily; 20 days
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。
可选溶剂
浓度溶剂体积质量
1 mg
5 mg
10 mg
25 mg
DMSO
1 mM
6.3992 mL
31.9959 mL
63.9918 mL
159.9795 mL
5 mM
1.2798 mL
6.3992 mL
12.7984 mL
31.9959 mL
10 mM
0.6399 mL
3.1996 mL
6.3992 mL
15.9980 mL
15 mM
0.4266 mL
2.1331 mL
4.2661 mL
10.6653 mL
20 mM
0.3200 mL
1.5998 mL
3.1996 mL
7.9990 mL
25 mM
0.2560 mL
1.2798 mL
2.5597 mL
6.3992 mL
30 mM
0.2133 mL
1.0665 mL
2.1331 mL
5.3327 mL
40 mM
0.1600 mL
0.7999 mL
1.5998 mL
3.9995 mL
50 mM
0.1280 mL
0.6399 mL
1.2798 mL
3.1996 mL
60 mM
0.1067 mL
0.5333 mL
1.0665 mL
2.6663 mL
80 mM
0.0800 mL
0.3999 mL
0.7999 mL
1.9997 mL
100 mM
0.0640 mL
0.3200 mL
0.6399 mL
1.5998 mL
Help & FAQs
Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
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