1. 天然产物
  2. 植物 黄酮类
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  5. 6,7,4'-Trihydroxyflavanone

6,7,4'-Trihydroxyflavanone是一种具有多种药理活性的化合物,具有抗风湿、抗缺血、抗炎、抗破骨细胞生成和保护T细胞免受METH诱导的去活化的活性。6,7,4'-Trihydroxyflavanone在神经毒性研究中显示出潜在的保护作用,可以用于抑制因METH而导致神经退行性疾病的患者。6,7,4'-Trihydroxyflavanone通过上调Nrf2/HO-1和PI3K/Akt/mTOR信号通路,从而抑制METH诱导的神经毒性。6,7,4'-Trihydroxyflavanone还能够诱导Nrf2核转位和HO-1表达,从而进一步增强其对 neuronal cells 的保护作用。

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6,7,4'-Trihydroxyflavanone Chemical Structure

6,7,4'-Trihydroxyflavanone Chemical Structure

CAS No. : 189689-31-4

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生物活性

6,7,4'-Trihydroxyflavanone is a compound with multiple pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic and protective T-cells from METH-induced deactivation. 6,7,4'-Trihydroxyflavanone has shown potential protective effects in neurotoxicity studies and can be used to inhibit patients with neurodegenerative diseases caused by METH. 6,7,4'-Trihydroxyflavanone inhibits METH-induced neurotoxicity by upregulating the Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways. 6,7,4'-Trihydroxyflavanone can also induce Nrf2 nuclear translocation and HO-1 expression, further enhancing its protective effect on neuronal cells[1].

分子量

272.25

Formula

C15H12O5

CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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产品名称:
6,7,4'-Trihydroxyflavanone
目录号:
HY-N9602
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