2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt JAK/STAT Signaling Apoptosis Autophagy
  3. Src PI3K JNK STAT EGFR Apoptosis Autophagy
  4. Peruvoside

Peruvoside  (Synonyms: Encordin)

目录号: HY-108016 纯度: 99.32%
COA 产品使用指南

摩尔计算器

Peruvoside 是一种有效的 Src，PI3K，JNK ，STAT，和 EGFR的抑制剂。Peruvoside 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，在乳腺癌、肺癌、肝癌和白血病中具有广谱的抗肿瘤活性。Peruvoside 对正义 RNA 病毒具有广谱、强效的抗病毒活性。 Peruvoside 增加 Gefitinib (HY-50895) 耐药肿瘤细胞 (A549，PC9/gef和H1975) 的敏感性。。

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Peruvoside Chemical Structure

Peruvoside Chemical Structure

CAS No. : 1182-87-2

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Customer Review

Peruvoside 相关抗体

Top Publications Citing Use of Products

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Lck Fyn Blk

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Peruvoside is a potent inhibitor of Src, PI3K, JNK, STAT, and EGFR. Peruvoside induces apoptosis and autophagy and possesses a broad spectrum of anticancer activity in breast, lung, liver cancers and leukemia. Peruvoside is a broad-spectrum and potent antiviral activity against positive-sense RNA viruses. Peruvoside sensitizes Gefitinib (HY-50895)-resistant tumour cells (A549, PC9/gef and H1975) to Gefitinib[1][2][3][4].

体外研究
(In Vitro)

Peruvoside (50-5000 nM，24 小时) 抑制了 PC9，PC9/gef，H3255，和 H1975 细胞系的活力和增殖[1]。
Peruvoside (0.005-0.5 μM, 72 小时) 与 Gefitinib (0.01~0.5 μM) 联用时，增强了 A549， PC9/gef 和 H1975 细胞对 Gefitinib 的敏感程度[1]。
Peruvoside (0-100 μM，24 小时) 诱导 MCF-7，HpG2 和 A549 细胞的周期停滞和凋亡[2。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Peruvoside 相关抗体:

Cell Proliferation Assay[1]

Cell Line: PC9, PC9/gef, H3255, and H1975 cell lines
Concentration: 0, 0.01, 0.05, 0.1, 0.5, 1 μM
Incubation Time: 24, 48, 72, 96 h.
Result: Inhibited the viabilities of TKI-sensitive and TKI-resistant cell lines at all tested time points.
Inhibited the EGFR-mutant lung cancer cell viability and proliferation with 24 h IC50s of 48 nM, 74 nM, 67 nM, 143 nM, 277 nM and 428 nM for A549, PC9, PC9/gef, H3255, H1975 and BEAS-2B cells, respectively.
Significantly inhibited the proliferation of A549 (48, 72, and 96 h) and H3255 (24, 48, 72, and 96 h) lungcancer cells.

Cell Viability Assay[1]

Cell Line: A549, PC9/gef and H1975 cell lines
Concentration: 0.005, 0.0075, 0.01, 0.025, 0.05, 0.5 μM (in combination with 0.01, 0.05, 0.1, 0.25, 0.5 μM Gefitinib)
Incubation Time: 72 h.
Result: Had synergistic effects on A549 cells at the combination of 0.005, 0.075, or 0.01 μM and a low dose of gefitinib (0.01 or 0.05 μM).
Increased the sensitivity of PC9/gef and H1975 cells to Gefitinib at 0.025 or 0.05 μM.

Apoptosis Analysis[2]

Cell Line: MCF-7, A549 and HepG2 cell lines
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest and apoptosis with lethal concentrations of IC50 for (MCF-7 - 100 nM), (A549 – 100 nM) and (HepG2 - 100 nM), respec-tively.
Arrested cell cycle at G0/G1 in MCF-7, A549 and HepG2 cells.
Significantly decreased the transcription of Chk1, Chk2, CDK6 and Cyclin D1 cell cycle genes in MCF-7, A549, and HepG2 cells.
体内研究
(In Vivo)

Peruvoside (0.1 mg/kg，腹腔注射；一天一次，连续 28 天) 抑制肺癌小鼠模型的肿瘤生长[1]。
Peruvoside (0.59 mg/kg，腹腔注射；一天一次，连续 7 天) 降低了 EV-A71 感染小鼠模型的死亡率[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lung cancer mouse model[1]
Dosage: 0.1 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 28 days
Result: Reduced the tumour size to 129.9 mm3, which was significantly smaller than the control group (348 mm3).
Significantly decreased levels of phosphorylated Src Y419 in tumour tissues compared with control tissues.
Animal Model: EV-A71-infected mice model[4]
Dosage: 0.59 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 7 days
Result: Substantially reduced clinical scores based on physical symptoms of body weight, activity,breathing, movement, and dehydration.
Showed about 6 log reduction in viral titre with 99.9% efficacy in inhibiting virus.
分子量

548.66

Formula

C30H44O9
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 250 mg/mL (455.66 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8226 mL 9.1131 mL 18.2262 mL
5 mM 0.3645 mL 1.8226 mL 3.6452 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Peruvoside 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8226 mL 9.1131 mL 18.2262 mL 45.5656 mL
5 mM 0.3645 mL 1.8226 mL 3.6452 mL 9.1131 mL
10 mM 0.1823 mL 0.9113 mL 1.8226 mL 4.5566 mL
15 mM 0.1215 mL 0.6075 mL 1.2151 mL 3.0377 mL
20 mM 0.0911 mL 0.4557 mL 0.9113 mL 2.2783 mL
25 mM 0.0729 mL 0.3645 mL 0.7290 mL 1.8226 mL
30 mM 0.0608 mL 0.3038 mL 0.6075 mL 1.5189 mL
40 mM 0.0456 mL 0.2278 mL 0.4557 mL 1.1391 mL
50 mM 0.0365 mL 0.1823 mL 0.3645 mL 0.9113 mL
60 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7594 mL
80 mM 0.0228 mL 0.1139 mL 0.2278 mL 0.5696 mL
100 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.4557 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peruvoside1182-87-2EncordinSrcPI3KJNKSTATEGFRApoptosisAutophagyPhosphoinositide 3-kinasec-Jun N-terminal kinaseEpidermal growth factor receptorErbB-1HER1non-small-cell lung carcinomalung cancerA549PC9/gefH1975GefitinibNSCLCleukemiaPositive-sense RNA virusesInhibitorinhibitorinhibit

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