2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB PI3K/Akt/mTOR
  3. Apoptosis Reactive Oxygen Species PI3K Akt
  4. Anticancer agent 235

Anticancer agent 235 (Compound 49) 是 PI3K/AKT/mTOR 信号通路的调节剂，可以促进活性氧 (ROS) 的产生，降低线粒体膜电位，从而抑制癌细胞 HCT116，Caco-2，AGS 和 SMMC-772 的增殖 (IC50 为 0.35-26.9 μM)。Anticancer agent 235 在 G2/M 期阻滞细胞周期，诱导 HCT-116 细胞凋亡 (apoptosis)。

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Anticancer agent 235 Chemical Structure

Anticancer agent 235 Chemical Structure

CAS No. : 2411108-21-7

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Anticancer agent 235 相关抗体

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生物活性

Anticancer agent 235 (Compound 49) is a modulator for PI3K/AKT/mTOR pathway, that promotes the generation of ROS, reduces the mitochondrial membrane potential, and thereby inhibits the proliferation of cancer cells HCT116, Caco-2, AGS and SMMC-772 with IC50 of 0.35-26.9 μM. Anticancer agent 235 arrests the cell cycle at G2/M phase, and induces apoptosis in HCT116[1].

分子量

296.75

Formula

C17H13ClN2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 235 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 2352411108-21-7Anticancer agent235Anticancer agent-235ApoptosisReactive Oxygen SpeciesPI3KAktPhosphoinositide 3-kinasePKBProtein kinase Bcolorectal cancerHCT116Caco-2AGSSMMC-772HIECPANC-1Inhibitorinhibitorinhibit

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