1. PI3K/Akt/mTOR Metabolic Enzyme/Protease GPCR/G Protein
  2. PI3K Lipase G Protein-coupled Receptor Kinase (GRK)
  3. LAS195319

LAS195319 是一种具有口服活性且强效的 PI3Kδ 抑制剂,其 IC50 值为 0.5 nM。LAS195319 也是一种对广泛的蛋白质,脂质激酶和 GPCRs 具有高度选择性的抑制剂。LAS195319 可以抑制中性粒细胞和嗜酸粒细胞的浸润。LAS195319 有望用于哮喘和慢性阻塞性肺疾病 (COPD) 等呼吸系统疾病的研究。

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LAS195319 Chemical Structure

LAS195319 Chemical Structure

CAS No. : 1605328-04-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)[1].

分子量

594.65

Formula

C29H26N10O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
LAS195319
目录号:
HY-123862
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