2. PI3K/Akt/mTOR
  3. PI3K
  4. SR-3-65

SR-3-65 (compound 6) 是一种 Indisulam (HY-13650) 衍生物，能抑制胃癌细胞的迁移。SR-3-65 减弱 PI3K/AKT/GSK-3β/β-catenin 信号通路。

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SR-3-65 Chemical Structure

SR-3-65 Chemical Structure

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SR-3-65 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR-3-65 (compound 6) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. SR-3-65 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway[1].

体外研究
(In Vitro)

SR-3-65 (0.0001-100 µM, 48h) 抑制 AGS 细胞生长, IC50值为 24.75 μM[1]。
SR-3-65(10 µM, 48-72 h) 在 AGS 和 MGC803 细胞中显示出抗迁移活性[1]。
SR-3-65(10 µM, 48 h) 在 AGS 和 MGC803 细胞中上调 E-cadherin，下调 N-cadherin 和 vimentin 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SR-3-65 相关抗体:

Cell Viability Assay[1]

Cell Line: AGS cells
Concentration: 0.0001-100 µM
Incubation Time: 48 h
Result: Inhibited the cell growth of AGS cells with the IC50 of 24.75 μM。

Cell Migration Assay [1]

Cell Line: AGS and MGC803 cells
Concentration: 10 µM
Incubation Time: 48-72 h
Result: Showed anti-migration activity in AGS and MGC803 cells.

Western Blot Analysis[1]

Cell Line: MGC803 cells
Concentration: 10 µM
Incubation Time: 48 h
Result: Upregulated E-cadherin and downregulated N-cadherin and vimentin.
分子量

399.77

Formula

C16H9ClF3N3O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SR-3-65 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR-3-65PI3KPhosphoinositide 3-kinaseAGSindisulam derivativesInhibitory effectMigrationMGC803Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-161362
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