Follistatin-like 1/FSTL1 蛋白, Human (His)

Follistatin-like 1 (FSTL1) protein is a secreted glycoprotein that contributes to angiogenesis, immune response regulation, and cell proliferation. It aids in the development of the central nervous system, skeletal system, lungs and ureters. Follistatin-like 1/FSTL1 Protein, Human (His) is the recombinant human-derived Follistatin-like 1/FSTL1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Follistatin-like 1/FSTL1 Protein, Human (His) is 288 a.a., with molecular weight of 30-38 kDa.

卵泡抑素样 1 (FSTL1) 蛋白是一种分泌型糖蛋白，在多种生理过程中发挥作用，包括血管生成、免疫反应调节、细胞增殖和分化。它参与中枢神经系统、骨骼系统、肺和输尿管的发育。FSTL1 通过 AKT 依赖性机制促进内皮细胞存活、迁移和分化为网络结构。它还支持心肌细胞的存活。FSTL1 通过激活细胞表面的各种受体（例如 DIP2A、TLR4 或 BMP 受体）来启动不同的信号级联反应。它形成同二聚体并与 SCN10A 相互作用。FSTL1 还与 DIP2A 相互作用，DIP2A 可能充当 FSTL1 的细胞表面受体。此外，FSTL1 与 BMP4 和 CD14 相互作用，后者相互作用促进 TLR4 介导的信号级联。

Immobilized Follistatin-like 1/FSTL1 Protein, Human (His) at 10 μg/mL (100 μl/well) can bind Recombinant Human/Mouse/Rat BMP-2.*:Biotinylated by NHS-biotin prior to testing.The ED₅₀ for this effect is ≤0.5 μg/mL.

Human

E. coli

C-6*His

Q12841 (E21-I308)

11167  [NCBI]

EEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI

30-38 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.