1. Gene
  2. FSTL1 - follistatin like 1 Gene

FSTL1 - follistatin like 1 Gene

中文名称:卵泡抑素样 1

种属: Homo sapiens

同用名: FRP; FSL1; OCC1; OCC-1; tsc36; MIR198

基因 ID: 11167 | 基因类型: protein coding

关于 FSTL1

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:120,392,293-120,450,992 (from NCBI)

This gene has 10 transcripts (splice variants), 233 orthologues and 6 paralogues. Broad expression in placenta (RPKM 238.4), gall bladder (RPKM 177.0) and 21 other tissues.

功能概要

该基因编码的蛋白质与卵泡抑素相似,卵泡抑素是一种激活素结合蛋白。它包含一个 FS 模块,一个含有 10 个保守半胱氨酸残基的卵泡抑素样序列。该基因产物被认为是与类风湿性关节炎相关的自身抗原。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein with similarity to Follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

FSTL1 基因产物(1)

mRNA Protein Name
NM_007085.5 NP_009016.1 follistatin-related protein 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19060904 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FSTL1 蛋白结构

FOLN

FOLN: Follistatin/Osteonectin-like EGF domain (31 - 52)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (58 - 98)

  • 0
  • 100
  • 200
  • 308 a.a.
蛋白主名 其他名称

follistatin-related protein 1

follistatin-like protein 1

重组 FSTL1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70412 Follistatin-like 1/FSTL1 Protein, Human (HEK293, His) Q12841 (E21-I308) ≥95%
HY-P72640 Follistatin-like 1/FSTL1 Protein, Human (His) Q12841 (E21-I308) ≥95%

关联疾病

疾病名称 别名
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Coronary Aneurysm

Aneurysm Of Coronary Vessels

Aneurysmal Lesion Of Coronary Artery

Arteriovenous Aneurysm Of Coronary Vessels

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FSTL1 RGD RGD:68955
Bos taurus FSTL1 VGNC VGNC:29135
Macaca mulatta FSTL1 VGNC VGNC:72824
Canis familiaris FSTL1 VGNC VGNC:49898
Mus musculus FSTL1 MGD MGI:102793
Felis catus FSTL1 VGNC VGNC:62380
Others FSTL1 NCBI