CD14 - CD14 molecule Gene

中文名称：CD14 分子

种属: Homo sapiens

基因 ID: 929 | 基因类型: protein coding

关于 CD14

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,631,732-140,633,701 (from NCBI)

This gene has 4 transcripts (splice variants) and 118 orthologues. Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues.

功能概要

该基因编码的蛋白质是一种表面抗原，优先在单核细胞/巨噬细胞上表达。它与其他蛋白质合作，介导对细菌脂多糖和病毒的先天免疫反应。该基因已被确定为治疗 SARS-CoV-2 感染患者的候选靶标，可能会减轻或抑制严重的炎症反应。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2020 年 8 月]

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with Other proteins to mediate the innate immune response to Bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]

CD14 基因产物(4)

mRNA	Protein	Name
NM_000591.4	NP_000582.1	monocyte differentiation antigen CD14 precursor
NM_001040021.3	NP_001035110.1	monocyte differentiation antigen CD14 precursor
NM_001174104.2	NP_001167575.1	monocyte differentiation antigen CD14 precursor
NM_001174105.2	NP_001167576.1	monocyte differentiation antigen CD14 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables lipopolysaccharide binding	IDA IDA: 通过直接分析推断	12594207	GOA
enables lipopolysaccharide immune receptor activity	IDA IDA: 通过直接分析推断	15294986	GOA
enables lipoteichoic acid binding	IDA IDA: 通过直接分析推断	12594207	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16880211	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell surface pattern recognition receptor signaling pathway	IDA IDA: 通过直接分析推断	15294986	GOA
involved in cellular response to diacyl bacterial lipopeptide	IDA IDA: 通过直接分析推断	16880211	GOA
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	12594207	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: 通过突变表型推断	8612135	GOA
acts upstream of or within cellular response to lipoteichoic acid	IDA IDA: 通过直接分析推断	12594207	GOA
involved in cellular response to molecule of bacterial origin	IDA IDA: 通过直接分析推断	15039339	GOA
involved in cellular response to triacyl bacterial lipopeptide	IDA IDA: 通过直接分析推断	16880211	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: 通过突变表型推断	15039339	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	12594207	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	8612135	GOA
involved in toll-like receptor 4 signaling pathway	IDA IDA: 通过直接分析推断	27986454	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	16880211	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	3385210	GOA
is active in extracellular space	IDA IDA: 通过直接分析推断	7537731	GOA
part of lipopolysaccharide receptor complex	IDA IDA: 通过直接分析推断	11274165	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	16880211	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD14 蛋白结构

LRR_6

LRR_1

0
100
200
300
375 a.a.

蛋白主名

其他名称

monocyte differentiation antigen CD14

myeloid cell-specific leucine-rich glycoprotein

CD14 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CD14	P08571	FSTL1	Homo sapiens	Q12841	SPR	20860622
种属内	CD14	P08571	FSTL1	Homo sapiens	Q12841	FACS	22265692

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD14 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7786	CD14 Protein, Human (HEK293, His)	P08571 (T20-C352)	≥95%
HY-P74333	CD14 Protein, Human (HEK293, Fc)	P08571 (T20-C352)	≥95%

关联疾病

疾病名称

别名

Mycobacterium Chelonae

Croup

Acute Obstructive Laryngitis	Laryngotracheobronchitis
Acute Laryngotracheobronchitis	Croup Syndrome
Acute Laryngitis With Obstruction	Obstructive Laryngitis
Obstructive Laryngitis Nos	Obstructive Laryngotracheitis Nos

Monocytic Leukemia

Monocytic Leukaemia	Schilling'S Leukaemia
Schilling'S Leukemia	M5b Acute Differentiated Monocytic Leukemia

Paroxysmal Nocturnal Hemoglobinuria

Marchiafava-Micheli Disease	Pnh
Hemoglobinuria, Paroxysmal	Marchiafava-Micheli Syndrome
Paroxysmal Hemoglobinuria Nocturnal	Nocturnal Haemoglobinuria
Nocturnal Paroxysmal Haematuria	Nocturnal Paroxysmal Haemoglobinaemia

Mycobacterium Kansasii

Infection Due To Mycobacterium Kansasii

Leukemia, Acute Monocytic

Acute Monocytic Leukemia	Acute Monoblastic Leukemia And Acute Monocytic Leukemia
Acute Monocytic Leukaemia	Acute Monocytic Leukaemia Without Mention Of Remission
Acute Monocytic Leukemia Without Mention Of Remission	Acute Monocytic Leukemia, Fab M5
Acute Monocytic Leukemia, Morphology	Leukemia, Monocytic, Acute
M5b Acute Differentiated Monocytic Leukemia

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Viral Meningitis

Meningitis Viral	Meningitis, Viral
Viral Meningitis Nec

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Peritonitis

Retractile Mesenteritis	Sclerosing Mesenteritis
Acute Generalized Peritonitis	Primary Bacterial Peritonitis
Idiopathic Sclerosing Mesenteritis	Mesenteric Panniculitis
Peritoneal Retractile Mesenteritis	Liposclerotic Mesenteritis
Mesenteric Fibromatosis	Mesenteric Lipodystrophy
Mesenteric Lipogranuloma	Fibromatosis, Abdominal
Peritoneum Inflammation	Peritonitis Of Undetermined Cause
Peritonitis Of Unspecified Cause	Pelviperitonitis
Pelvic Peritonitis, Nos	Generalised Peritonitis Nos
Abdominal Peritonitis	Acute Idiopathic Peritonitis
Acute Lesser Sac Peritonitis	Acute Peritoneal Inflammation
Diffuse Peritonitis	Peritoneal Inflammation
Acute Primary Peritonitis	Pneumococcal Peritonitis

Melioidosis

Melioidosis, Susceptibility To	Acute And Fulminating Melioidosis
Nightcliff Gardener'S Disease	Pseudoglanders
Subacute And Chronic Melioidosis	Burkholderia Pseudomallei Infection
Whitmore Disease	Whitmore'S Disease
B Pseudomallei Infection	Epizootic Lymphangitis
Infection Due To Burkholderia Pseudomallei	Infection Due To Burkholderia Pseudomallei Nos
Infection Due To Malleomyces Pseudomallei	Infection Due To Pseudomonas Pseudomallei
Infection Due To Pseudomonas Pseudomallei Nos	Infection Due To Whitmore Bacillus
Stanton Disease

Arteriosclerosis

Arteriosclerotic Vascular Disease

Enterocolitis

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Ige Responsiveness, Atopic

ATOPY	Atopy, Susceptibility To
Ige, Elevated Level Of	IGER
Immunoglobulin E, Basic Level Of, In Serum	Ige, Level Of
Igel	Ige Response Underlying Allergic Asthma And Rhinitis
Atopic Hypersensitivity	Immediate Hypersensitivity

Viral Hepatitis

Animal Viral Hepatitis	Hepatitis, Viral, Animal
Human Viral Hepatitis	Viral Hepatitis With Hepatic Coma

Alcoholic Hepatitis

Acute Alcoholic Hepatitis	Acute Alcoholic Liver Disease
Hepatitis, Alcoholic	Hepatitis Alcoholic
Ah - [Alcoholic Hepatitis]	Ethanol Hepatitis

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Cutaneous Leishmaniasis

Diffuse Cutaneous Leishmaniasis	Asian Desert Cutaneous Leishmaniasis
Leishmaniasis, Cutaneous	Leproid Leishmaniasis
Leishmaniasis Diffuse Cutaneous	Leishmaniasis Cutaneous
Ethiopian Cutaneous Leishmaniasis	Old World Cutaneous Leishmaniasis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Diabetes Mellitus

Diabetes

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-135750	VAF347	Agonist	99.90%	否
HY-N9965	2'-Fucosyllactose	Inhibitor	99.95%	否
HY-101132	VB-201		/	否
HY-151399	Antimicrobial agent-5	Inhibitor	/	否
HY-161901	BC-1293	Inhibitor	/	否
HY-169067	10-Methoxy-canthin-6-one	Activator	/	否
HY-RS02189	CD14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CD14	VGNC	VGNC:70751
Rattus norvegicus	CD14	RGD	RGD:620588
Bos taurus	CD14	VGNC	VGNC:27003
Mus musculus	CD14	MGD	MGI:88318
Felis catus	CD14	VGNC	VGNC:60584
Canis familiaris	CD14	NCBI	NCBI:607076
Macaca fascicularis	CD14	NCBI	NCBI:102129342
Leporidae	CD14	NCBI
Others	CD14	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CD14 - CD14 molecule Gene

关于 CD14

功能概要

CD14 基因产物(4)

CD14 蛋白结构

CD14 蛋白互作信息

重组 CD14 蛋白

关联疾病

直系同源

热门区域

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CD14 - CD14 molecule Gene

关于 CD14

功能概要

CD14 基因产物(4)

CD14 蛋白结构

CD14 蛋白互作信息

重组 CD14 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z