2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. BC-1293

BC-1293 是 E3 连接酶亚基 FBXO24 的抑制剂。BC-1293 可破坏 FBXO24 与天冬氨酰-tRNA 合成酶 (DARS2) 之间的相互作用，并提高 DARS2 的水平。BC-1293 可提高 IL-1β、IL-9、MIP-2 和 TNF α 的水平，并在小鼠中表现出免疫刺激活性。

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BC-1293 Chemical Structure

BC-1293 Chemical Structure

CAS No. : 1219395-86-4

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BC-1293 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BC-1293 is an inhibitor for E3 ligase subunit FBXO24. BC-1293 disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) and increases the level of DARS2. BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, and exhibits immunostimulatory activity in mice[1].

分子量

492.59

Formula

C26H28N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BC-1293 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BC-12931219395-86-4BC1293BC 1293E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseC57BL/6J mouseBEAS-2BCD14 + THP-1Inhibitorinhibitorinhibit

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