ICOS 蛋白, Mouse (C137S, C138S, HEK293, His)

ICOS protein optimizes essential T-cell responses to foreign antigens, fostering proliferation, lymphokine secretion, up-regulation of cell-cell interaction molecules, and effective B-cell antibody secretion. Crucial for efficient T and B-cell communication, ICOS is vital for normal antibody responses to T-cell dependent antigens. While it doesn't increase interleukin-2 production, it superinduces interleukin-10 synthesis. Moreover, ICOS prevents apoptosis in pre-activated T-cells and plays a critical role in CD40-mediated immunoglobulin class switching. It exists as a homodimer connected by disulfide bonds. ICOS Protein, Mouse (C137S, C138S, HEK293, His) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-His labeled tag and C137S, C138S mutation. The total length of ICOS Protein, Mouse (C137S, C138S, HEK293, His) is 124 a.a., with molecular weight of 27-38 kDa.

ICOS蛋白增强T细胞对外来抗原的所有基本反应，包括增殖、淋巴因子的分泌、细胞间相互作用分子的上调，并为B细胞分泌抗体提供有效帮助。它对于促进 T 细胞和 B 细胞之间的有效通讯以及对 T 细胞依赖性抗原的正常抗体反应至关重要。虽然它不会增加白细胞介素 2 的产生，但它会促进白细胞介素 10 的合成。此外，它还可以防止预激活 T 细胞凋亡，并在 CD40 介导的免疫球蛋白同种型类型转换中发挥关键作用。 ICOS 以同二聚体形式存在，通过二硫键连接。

Mouse

HEK293

C-His

Q9WVS0 (E21-L144, C137S, C138S)

54167  [NCBI]

27-38 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.