2. Gene
  3. Icos - inducible T cell co-stimulator Gene

Icos - inducible T cell co-stimulator Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: H4; CCLP; AILIM; CRP-1; Ly115

基因 ID: 54167 | 基因类型: protein coding

关于 Icos

功能概要

Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Is integral component of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Apr 2022]

Icos 基因产物(1)

mRNA Protein Name
NM_017480.2 NP_059508.2 inducible T-cell costimulator precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10657606 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
10760791 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10760791 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

inducible T-cell costimulator

CD28 and CTLA-4-like protein

CD28-related protein 1

activation-inducible lymphocyte immunomediatory molecule

重组 Icos 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72619 ICOS Protein, Mouse (HEK293, His) Q9WVS0 (E21-L142) ≥95%
HY-P76397 ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) Q9WVS0 (E21-L144) ≥95%
HY-P78306 ICOS Protein, Mouse (C137S, C138S, HEK293, His) Q9WVS0 (E21-L144, C137S, C138S) ≥95%
HY-P78307 ICOS Protein, Mouse (HEK293, Fc) Q9WVS0 (E21-L144) ≥95%
HY-P78673 ICOS Protein, Mouse (C137S, C138S, HEK293, Fc) Q9WVS0 (E21-L144, C137S, C138S) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99420 Acazicolcept Antagonist 99.27% Phase 2
HY-P99474 Bertilimumab Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-162810 ICOS-IN-1 / 否
HY-RS06520 ICOS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W011267 (Z)-Methyl icos-11-enoate / 否
HY-166209 Ethyl 8(Z)-eicosenoate / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99679 Izuralimab Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Icos NCBI NCBI:29851
Macaca fascicularis Icos NCBI NCBI:102116512
Rattus norvegicus Icos NCBI NCBI:64545
Macaca mulatta Icos NCBI NCBI:705788
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