1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens Biotinylated Proteins
  3. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins
  4. ICOS/CD278 ICOS/CD278
  5. ICOS 蛋白, Mouse (Biotinylated, HEK293, Fc-Avi)

ICOS 蛋白, Mouse (Biotinylated, HEK293, Fc-Avi)

目录号: HY-P76397
产品使用指南

ICOS 蛋白优化 T 细胞对外来抗原的反应,促进增殖、淋巴因子分泌、细胞间相互作用分子的上调以及有效的 B 细胞抗体分泌。ICOS 对于 T 细胞和 B 细胞的有效通讯以及对 T 细胞依赖性抗原的正常抗体反应至关重要。ICOS 蛋白, Mouse (Biotinylated, HEK293, Fc-Avi) 是重组的 ICOS 蛋白,由 HEK293 表达,带有 C-Avi, C-hFc 标签。ICOS 蛋白, Mouse (Biotinylated, HEK293, Fc-Avi) 全长 142 个氨基酸,分子量约为 ~42.4 KDa。

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SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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描述

ICOS proteins optimize T cell responses to foreign antigens, promoting proliferation, lymphokine secretion, upregulation of cell-cell interaction molecules, and efficient B cell antibody secretion. ICOS is essential for efficient communication of T cells and B cells and for normal antibody responses to T cell-dependent antigens. ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is the recombinant mouse-derived ICOS protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) is 142 a.a., with molecular weight of ~42.4 KDa.

研究背景

ICOS蛋白增强T细胞对外源抗原的所有基本反应,包括增殖、淋巴因子分泌、细胞间相互作用分子的上调,并为B细胞分泌抗体提供有效帮助。它对于促进 T 细胞和 B 细胞之间的有效通讯以及对 T 细胞依赖性抗原的正常抗体反应至关重要。虽然它不会增加白细胞介素 2 的产生,但它会促进白细胞介素 10 的合成。此外,它还可以防止预激活 T 细胞凋亡,并在 CD40 介导的免疫球蛋白同种型类型转换中发挥关键作用。ICOS 以同二聚体形式存在,通过二硫键连接。

种属

Mouse

表达系统

HEK293

标签

C-Avi;C-hFc

蛋白编号

Q9WVS0 (M1-L142)

基因 ID
蛋白结构
N-term
ICOS (M1-L142)
Accession # Q9WVS0
hFc-Avi
C-term
同用名
Inducible T-cell costimulator; CD278; AILIM; CVID1; ICOS
分子量

Approximately 42.4 kDa.

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
ICOS Protein, Mouse (Biotinylated, HEK293, Fc-Avi)
目录号:
HY-P76397
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