JAM-B/CD322 蛋白, Mouse (HEK293, His)

JAM-B/CD322 protein regulates cellular processes through interactions with JAM3. It aids hematopoietic cell homing and retention in the bone marrow and facilitates leukocyte extravasation. JAM-B is involved in spermatogenesis, inhibits myelination, promotes myocyte fusion, and may contribute to angiogenesis. Its multifunctionality emphasizes its significance in cellular and physiological processes. JAM-B/CD322 Protein, Mouse (HEK293, His) is the recombinant mouse-derived JAM-B/CD322 protein, expressed by HEK293 , with C-His labeled tag. The total length of JAM-B/CD322 Protein, Mouse (HEK293, His) is 208 a.a., with molecular weight of ~37 kDa.

JAM-B/CD322 蛋白作为连接粘附分子，协调异型细胞间相互作用及其受体 JAM3，以调节不同的细胞过程。它在骨髓内造血干细胞和祖细胞的归巢和动员中发挥着至关重要的作用，有助于它们保留在骨髓基质细胞的表面。在白细胞外渗的情况下，JAM-B 不仅对于轮回至关重要，而且对于白细胞沿着内皮的束缚和滚动也至关重要，这一过程依赖于其与整合素 α-4/β-1 的结合。此外，JAM-B 参与精子发生，介导支持细胞和生殖细胞之间的相互作用，并有助于生殖细胞在支持细胞上的锚定，以及精子细胞分化过程中细胞极性复合物的组装。作为抑制性体树突信号，它可以防止神经元非轴突部分的髓鞘形成。此外，JAM-B 参与肌生成过程中的肌细胞融合，并可能在血管生成中发挥作用。JAM-B 的多方面功能强调了它在各种细胞和生理过程中的重要性。

Mouse

HEK293

C-His

Q9JI59 (F29-N236)

67374  [NCBI]

FSASKDHRQEVTVIEFQEAILACKTPKKTTSSRLEWKKVGQGVSLVYYQQALQGDFKDRAEMIDFNIRIKNVTRSDAGEYRCEVSAPTEQGQNLQEDKVMLEVLVAPAVPACEVPTSVMTGSVVELRCQDKEGNPAPEYIWFKDGTSLLGNPKGGTHNNSSYTMNTKSGILQFNMISKMDSGEYYCEARNSVGHRRCPGKRMQVDVLN

Approximately 37 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.