RON/MSPR 蛋白, Human (HEK293, His)

RON/MSPR protein is a receptor tyrosine kinase that transduces signals by binding to MST1 ligand and regulates cell survival, migration, and differentiation. Ligand binding induces RON autophosphorylation, creating docking sites for downstream molecules. RON/MSPR Protein, Human (HEK293, His) is the recombinant human-derived RON/MSPR protein, expressed by HEK293 , with C-His labeled tag.

RON/MSPR 蛋白是一种受体酪氨酸激酶，通过与 MST1 配体结合，充当细胞外基质的信号转导器。它在调节各种生理过程中发挥着至关重要的作用，包括细胞存活、迁移和分化。细胞表面的配体结合诱导 RON 在其胞内结构域上的自磷酸化，为下游信号分子创建对接位点。配体激活后，RON 与 PI3 激酶亚基 PIK3R1、PLCG1 或接头 GAB1 相互作用，导致多个信号级联的激活，例如 RAS-ERK、PI3 激酶-AKT 和 PLCgamma-PKC。RON 信号传导通过促进伤口部位的上皮细胞迁移、增殖和存活来促进伤口愈合反应。此外，RON 通过调节巨噬细胞的迁移和吞噬活性在先天免疫反应中发挥作用。另外，RON 还可以响应 MST1 配体以外的生长因子来促进细胞迁移和增殖等信号。

Measured by its binding ability in a functional ELISA. Immobilized MSP at 0.5 µg/mL (100 µL/well) can bind Biotinylated Recombinant Human RON. The ED₅₀ for this effect is 255.1 ng/mL.

Human

HEK293

C-His

Q04912 (E25-L571)

4486  [NCBI]

Approximately 70 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.