MST1R - macrophage stimulating 1 receptor Gene

中文名称：巨噬细胞刺激 1 受体

种属: Homo sapiens

同用名: RON; SEA; PTK8; CD136; NPCA3; CDw136; p185-Ron

基因 ID: 4486 | 基因类型: protein coding

关于 MST1R

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,887,002-49,903,873 (from NCBI)

This gene has 13 transcripts (splice variants), 267 orthologues, 53 paralogues and is associated with 1 phenotype. Biased expression in skin (RPKM 17.5), stomach (RPKM 16.3) and 9 other tissues.

功能概要

该基因编码具有酪氨酸激酶活性的巨噬细胞刺激蛋白 (MSP) 的细胞表面受体。这种蛋白质的成熟形式是二硫键连接的 alpha 和 beta 亚基的异二聚体，由单链前体的蛋白水解切割产生。 β 亚基在 MSP 刺激下发生酪氨酸磷酸化。这种蛋白质在肺粘膜纤毛运输装置的纤毛上皮细胞上表达，并与 MSP 一起被认为参与宿主防御。可变剪接生成多个转录变体，编码不同的亚型，这些亚型可能会经历类似的蛋白水解过程。[RefSeq 提供，2016 年 1 月]

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]

MST1R 基因产物(3)

mRNA	Protein	Name
NM_001244937.3	NP_001231866.1	macrophage-stimulating protein receptor isoform 2 precursor
NM_001318913.2	NP_001305842.1	macrophage-stimulating protein receptor isoform 3 precursor
NM_002447.4	NP_002438.2	macrophage-stimulating protein receptor isoform 1 preproprotein

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables enzyme binding	IPI IPI: 通过物理相互作用推断	12676986	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15184888	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of MAP kinase activity	IDA IDA: 通过直接分析推断	12676986	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	12676986	GOA
involved in response to virus	IDA IDA: 通过直接分析推断	12676986	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MST1R 蛋白结构

Sema

TIG

Pkinase_Tyr

0
300
600
900
1200
1400 a.a.

蛋白主名

其他名称

macrophage-stimulating protein receptor

MSP receptor

MST1R 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MST1R	Q04912	PLXNB1	Homo sapiens	O43157	Anti Bait CoIP	15184888
种属内	MST1R	Q04912	PLXNB1	Homo sapiens	O43157	Anti Tag CoIP	15184888
种属内	MST1R	Q04912	PLXNB3	Homo sapiens	Q9ULL4	Anti Tag CoIP	15184888
种属内	MST1R	Q04912	PLXNB3	Homo sapiens	Q9ULL4	Anti Bait CoIP	15184888
种属内	MST1R	Q04912	MST1	Homo sapiens	P26927	SPR	22087277
种属内	MST1R	Q04912	MST1	Homo sapiens	P26927	Solution Sedimentation	25193665
种属内	MST1R	Q04912	PLXNB2	Homo sapiens	O15031	Anti Bait CoIP	15184888
种属内	MST1R	Q04912	PLXNB2	Homo sapiens	O15031	Anti Tag CoIP	15184888

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MST1R 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77180	RON/MSPR Protein, Human (HEK293, His)	Q04912 (E25-L571)	≥95%

MST1R 抗体

目录号	产品名	应用	反应物种
HY-P81384	RON Antibody (YA1129)	IHC-P	Human

关联疾病

疾病名称

别名

Nasopharyngeal Carcinoma 3

NPCA3	Nasopharyngeal Carcinoma, Susceptibility To, 3
Nasopharyngeal Carcinoma, 3	{Nasopharyngeal Carcinoma, Susceptibility To, 3}

Adenocarcinoma

Adenocarcinomas	Adenoacanthoma Of Unspecified Site
Adenocarcinoid Of Unspecified Site	Adenocarcinoid Tumour Of Unspecified Site
Adenocarcinoma And Carcinoid Combined Of Unspecified Site	Adenocarcinoma Nos

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Papillary Adenocarcinoma

Infiltrating And Papillary Adenocarcinoma	Infiltrating Papillary Adenocarcinoma
Adenocarcinoma Papillary	Adenocarcinoma, Papillary

Pancreatic Adenocarcinoma

Adenocarcinoma Of The Pancreas	Adenocarcinoma Of Pancreas
Pancreas Adenocarcinoma	Malignant Exocrine Neoplasm
Primary Pancreatic Adenocarcinoma	Adenocarcinoma Of Islet Cell Of Pancreas
Islet Cell Adenocarcinoma Of Unspecified Site	Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary

Arthrogryposis, Distal, Type 1c

DA1C	Distal Arthrogryposis Type 1c
Arthrogryposis, Distal, 1c

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2	SRTD2
Atd2	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 2

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-15514	Merestinib	Inhibitor	99.99%	Phase 2
HY-15514A	Merestinib dihydrochloride	Inhibitor	99.36%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08730	MST1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MST1R	VGNC	VGNC:68331
Macaca mulatta	MST1R	VGNC	VGNC:74941
Rattus norvegicus	MST1R	RGD	RGD:1306465
Canis familiaris	MST1R	VGNC	VGNC:43452
Mus musculus	MST1R	MGD	MGI:99614
Bos taurus	MST1R	VGNC	VGNC:31708
Others	MST1R	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MST1R - macrophage stimulating 1 receptor Gene

关于 MST1R

功能概要

MST1R 基因产物(3)

MST1R 蛋白结构

MST1R 蛋白互作信息

重组 MST1R 蛋白

MST1R 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

MST1R - macrophage stimulating 1 receptor Gene

关于 MST1R

功能概要

MST1R 基因产物(3)

MST1R 蛋白结构

MST1R 蛋白互作信息

重组 MST1R 蛋白

MST1R 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z