1. Gene
  2. PLXNB3 - plexin B3 Gene

PLXNB3 - plexin B3 Gene

中文名称:丛素 B3

种属: Homo sapiens

同用名: PLEXR; PLXN6; PLEXB3

基因 ID: 5365 | 基因类型: protein coding

关于 PLXNB3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,764,249-153,779,341 (from NCBI)

This gene has 9 transcripts (splice variants), 172 orthologues and 8 paralogues. Broad expression in brain (RPKM 10.9), salivary gland (RPKM 4.4) and 16 other tissues.

功能概要

该基因编码的蛋白质是丛蛋白家族的一员。它作为信号蛋白 5A 的受体发挥作用,并在轴突导向、侵入性生长和细胞迁移中发挥作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2009 年 9 月]

The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

PLXNB3 基因产物(2)

mRNA Protein Name
NM_001163257.2 NP_001156729.1 plexin-B3 isoform 2
NM_005393.3 NP_005384.2 plexin-B3 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell-cell adhesion mediator activity IPI
IPI: 通过物理相互作用推断
16122393 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15184888 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
15218527 GOA
enables semaphorin receptor activity IDA
IDA: 通过直接分析推断
15218527 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell chemotaxis IDA
IDA: 通过直接分析推断
15218527 GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: 通过直接分析推断
16122393 GOA
involved in negative regulation of GTPase activity IMP
IMP: 通过突变表型推断
20696765 GOA
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
15218527 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
20696765 GOA
involved in positive chemotaxis IDA
IDA: 通过直接分析推断
15218527 GOA
involved in positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
19850054 GOA
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
16122393 GOA
involved in semaphorin-plexin signaling pathway IDA
IDA: 通过直接分析推断
15218527 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
16122393 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PLXNB3 蛋白结构

Sema

Sema: Sema domain (55 - 428)

PSI

PSI: Plexin repeat (474 - 521)

TIG

TIG: IPT/TIG domain (835 - 924)

TIG

TIG: IPT/TIG domain (927 - 1011)

TIG

TIG: IPT/TIG domain (1165 - 1242)

Plexin_cytopl

Plexin_cytopl: Plexin cytoplasmic RasGAP domain (1326 - 1876)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1909 a.a.
蛋白主名 其他名称

plexin-B3

plexin 6

PLXNB3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLXNB3 Q9ULL4 FSCN1 Homo sapiens Q16658 21706053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Glioma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PLXNB3 VGNC VGNC:68920
Canis familiaris PLXNB3 VGNC VGNC:44724
Mus musculus PLXNB3 MGD MGI:2154240
Rattus norvegicus PLXNB3 RGD RGD:1560615
Bos taurus PLXNB3 VGNC VGNC:33063
Macaca mulatta PLXNB3 VGNC VGNC:76189