1. Gene
  2. FSCN1 - fascin actin-bundling protein 1 Gene

FSCN1 - fascin actin-bundling protein 1 Gene

中文名称:肌成束蛋白肌动蛋白结合蛋白 1

种属: Homo sapiens

同用名: HSN; SNL; p55; FAN1

基因 ID: 6624 | 基因类型: protein coding

关于 FSCN1

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,592,816-5,606,655 (from NCBI)

This gene has 5 transcripts (splice variants), 254 orthologues and 2 paralogues. Broad expression in brain (RPKM 42.7), placenta (RPKM 36.2) and 24 other tissues.

功能概要

该基因编码肌动蛋白结合蛋白肌成束蛋白家族的一个成员。 Fascin 蛋白将 F-肌动蛋白组织成平行束,并且是形成基于肌动蛋白的细胞突起所必需的。编码的蛋白质在细胞迁移、运动、粘附和细胞相互作用中起着关键作用。已知该基因的表达受几种微小 RNA 的调节,并且该基因的过表达可能通过增加细胞运动性在多种类型的癌症的转移中发挥作用。该基因的表达也是霍奇金淋巴瘤中 Reed-Sternberg 细胞的标志。该基因的假基因位于 15 号染色体的长臂上。[RefSeq 提供,2011 年 9 月]

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several MicroRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of Cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

FSCN1 基因产物(1)

mRNA Protein Name
NM_003088.4 NP_003079.1 fascin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
8999969 GOA
enables actin filament binding IDA
IDA: 通过直接分析推断
8999969 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15161933 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
9571235 GOA
involved in actin filament bundle assembly IDA
IDA: 通过直接分析推断
20393565 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
20393565 GOA
involved in cell motility IDA
IDA: 通过直接分析推断
9571235 GOA
involved in cell-cell junction assembly IDA
IDA: 通过直接分析推断
9571235 GOA
involved in establishment of apical/basal cell polarity IDA
IDA: 通过直接分析推断
9571235 GOA
involved in microspike assembly IDA
IDA: 通过直接分析推断
9571235 GOA
involved in microspike assembly IMP
IMP: 通过突变表型推断
20137952 GOA
involved in parallel actin filament bundle assembly IDA
IDA: 通过直接分析推断
21685497 GOA
involved in positive regulation of extracellular matrix disassembly IDA
IDA: 通过直接分析推断
20137952 GOA
involved in positive regulation of filopodium assembly IDA
IDA: 通过直接分析推断
9571235 GOA
involved in positive regulation of filopodium assembly IMP
IMP: 通过突变表型推断
20137952 GOA
involved in positive regulation of lamellipodium assembly IDA
IDA: 通过直接分析推断
9571235 GOA
involved in positive regulation of podosome assembly IDA
IDA: 通过直接分析推断
20137952 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
20137952 GOA
involved in regulation of microvillus assembly IDA
IDA: 通过直接分析推断
9571235 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
3525578 GOA
located in cell projection membrane IDA
IDA: 通过直接分析推断
9571235 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
9571235 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9571235 GOA
located in cytoskeleton IDA
IDA: 通过直接分析推断
9571235 GOA
located in filopodium IDA
IDA: 通过直接分析推断
3525578 GOA
located in microspike IDA
IDA: 通过直接分析推断
3525578 GOA
located in microvillus IDA
IDA: 通过直接分析推断
9571235 GOA
located in podosome IDA
IDA: 通过直接分析推断
20137952 GOA
located in ruffle IDA
IDA: 通过直接分析推断
3525578 GOA
located in stress fiber IDA
IDA: 通过直接分析推断
3525578 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FSCN1 蛋白结构

Fascin

Fascin: Fascin domain (21 - 134)

Fascin

Fascin: Fascin domain (143 - 256)

Fascin

Fascin: Fascin domain (268 - 378)

Fascin

Fascin: Fascin domain (391 - 493)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
蛋白主名 其他名称

fascin

55 kDa actin-bundling protein

FSCN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FSCN1 Q16658 PLXNB3 Homo sapiens Q9ULL4
Anti Bait CoIP
21706053
种属内
FSCN1 Q16658 YWHAZ Homo sapiens P63104
Pull Down
20603015
种属内
FSCN1 Q16658 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
FSCN1 Q16658 FANCD2 Homo sapiens Q9BXW9
Pull Down
20603015
种属内
FSCN1 Q16658 FANCD2 Homo sapiens Q9BXW9
Anti Tag CoIP
20603015
种属内
FSCN1 Q16658 FANCD2 Homo sapiens Q9BXW9
Anti Bait CoIP
20603015
种属内
FSCN1 Q16658 FANCD2 Homo sapiens Q9BXW9
IF
20603015
种属内
FSCN1 Q16658 MLH1 Homo sapiens P40692
Anti Bait CoIP
20603015
种属内
FSCN1 Q16658 MLH1 Homo sapiens P40692
Anti Tag CoIP
20603015
种属内
FSCN1 Q16658 MLH1 Homo sapiens P40692
Pull Down
20603015
种属间: 跨种属相互作用 种属内: 同种属相互作用

FSCN1 抗体

目录号 产品名 应用 反应物种
HY-P80667 Fascin Antibody WB, IHC-F, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat, Monkey

关联疾病

疾病名称 别名
Inverted Papilloma

Inverted Papilloma, Squamous Cell

Papilloma Inverted

Papilloma, Inverted

Inverted Squamous Cell Papilloma

Castleman Disease

Angiofollicular Ganglionic Hyperplasia

Angiofollicular Lymph Hyperplasia

Giant Lymph Node Hyperplasia

Castleman'S Disease

Angiofollicular Lymph Node Hyperplasia

Lymphoid Hamartoma

Benign Giant Lymphoma

Angiolymphoid Hyperplasia

Langerhans Cell Histiocytosis

Histiocytosis X

Lch

Langerhans Cell Granulomatosis

Langerhans-Cell Histiocytosis

Letterer-Siwe Disease

Hashimoto-Pritzger Disease

Histiocytosis, Langerhans-Cell

Langerhan'S Cell Histiocytosis

Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes

Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes

Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes

Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb

Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck

Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck

Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb

Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites

Letterer-Siwe Disease Involving Spleen

Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes

Letterer-Siwe Disease Of Intrapelvic Lymph Nodes

Letterer-Siwe Disease Of Intrathoracic Lymph Nodes

Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb

Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb

Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck

Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck

Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb

Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb

Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites

Letterer-Siwe Disease Of Spleen

Familial Letterer-Siwe Disease

Langerhans-Cell Histiocytosis Nos

Autosomal Recessive Nonsyndromic Deafness 36

Autosomal Recessive Deafness 36

Dfnb36

Deafness, Autosomal Recessive 36, With Or Without Vestibular Involvement

Deafness, Autosomal Recessive 36

Mirror Agnosia
Anaplastic Large Cell Lymphoma

Alcl

Cd30 Positive Anaplastic Large Cell Lymphoma

Ki-1 Positive Anaplastic Large Cell Lymphoma

Primary Systemic Alcl

Sacl

Ki-1+ Anaplastic Large Cell Lymphoma

Juvenile Xanthogranuloma

Multiple Eruptive Juvenile Xanthogranuloma

Naevoxanthoendothelioma

Xanthoma Neviforme

Xanthogranuloma, Juvenile

Reticulosarcoma

Histiocytic Lymphoma

Large-Cell Lymphomas

Lymphoma, Large-Cell

Lymphoma Large Cell

Diffuse Large B-Cell Lymphoma

Histiocytic Sarcoma

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Papilloma

Papillomatosis

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Histiocytic Sarcoma

Malignant Histiocytosis

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Larynx

Squamous Cell Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Head And Neck

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Usher Syndrome, Type I

USH1

Usher Syndrome Type 1

Us1

Usher Syndrome, Type 1b

Usher Syndrome Type 1e

Retinitis Pigmentosa And Congenital Deafness

Usher Syndrome, Type Ie

USH1E

Usher Syndrome, Type 1e

Usher Syndrome, Type 1a

Usher Syndrome, Type Ib

Usher Syndrome Type 1b

Usher Syndrome Type Ie

Usher Syndrome Type I

Usher 1

Usher Syndrome, Type 1

Ush1a

Usher Syndrome, Type I, French Variety

Usher Syndrome, Type Ia

Usher Syndrome 1b

USH1B

Usher'S Syndrome Type 1b

Usher Syndrome Type Ib

Ushib

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified

Parkinson Disease 4, Autosomal Dominant

Autosomal Dominant Parkinson Disease 4

PARK4

Parkinson Disease 4, Autosomal Dominant Lewy Body

Parkinson Disease 4

Parkinson'S Disease 4

Autosomal Dominant Lewy Body Parkinson Disease 4

Autosomal Dominant Parkinson'S Disease 4

Parkinson Disease 4 Autosomal Dominant Lewy Body

Parkinson Disease Autosomal Dominant 4

Parkinson Disease Familial Type 4

Parkinson Disease, Type 4

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus FSCN1 VGNC VGNC:29126
Rattus norvegicus FSCN1 RGD RGD:1583309
Mus musculus FSCN1 MGD MGI:1352745
Macaca mulatta FSCN1 VGNC VGNC:72714
Felis catus FSCN1 VGNC VGNC:80575
Canis familiaris FSCN1 VGNC VGNC:40990