2. Gene
  3. MST1 - macrophage stimulating 1 Gene

MST1 - macrophage stimulating 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：巨噬细胞刺激 1

种属: Homo sapiens

同用名: MSP; HGFL; NF15S2; D3F15S2; DNF15S2

基因 ID: 4485 | 基因类型: protein coding

关于 MST1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,683,947-49,689,474 (from NCBI)

This gene has 21 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 45.2), duodenum (RPKM 24.6) and 13 other tissues.

功能概要

由该基因编码的蛋白质包含四个 kringle 结构域和一个丝氨酸蛋白酶结构域，类似于在肝生长因子中发现的蛋白质。尽管存在丝氨酸蛋白酶结构域，但编码的蛋白质可能没有任何蛋白水解活性。这种蛋白质的受体是 RON 酪氨酸激酶，它在激活后会刺激肺纤毛上皮细胞的纤毛运动。这种蛋白质被分泌和切割形成由二硫键桥接的 α 链和 β 链。[RefSeq 提供，2010 年 1 月]

The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]

MST1 基因产物(6)

mRNA Protein Name
NM_001393581.1 NP_001380510.1 hepatocyte growth factor-like protein isoform 2 precursor
NM_001393582.1 NP_001380511.1 hepatocyte growth factor-like protein isoform 3 precursor
NM_001393583.1 NP_001380512.1 hepatocyte growth factor-like protein isoform 4 precursor
NM_001393584.1 NP_001380513.1 hepatocyte growth factor-like protein isoform 5 precursor
NM_001393585.1 NP_001380514.1 hepatocyte growth factor-like protein isoform 6 precursor
NM_020998.4 NP_066278.3 hepatocyte growth factor-like protein isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22087277 GOA
enables receptor tyrosine kinase binding IDA
IDA: 通过直接分析推断
22087277 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of gluconeogenesis IDA
IDA: 通过直接分析推断
19720831 GOA
involved in regulation of cAMP-dependent protein kinase activity IDA
IDA: 通过直接分析推断
19720831 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
7508914 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepatocyte growth factor-like protein

hepatocyte growth factor-like protein homolog

MST1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MST1 P26927 MST1R Homo sapiens Q04912
X-Ray Diffraction
25193665
种属内
MST1 P26927 SFT2D1 Homo sapiens Q8WV19
Validated Y2H
32296183
种属内
MST1 P26927 SFT2D1 Homo sapiens Q8WV19
Y2H Prey Pooling
32296183
种属内
MST1 P26927 SFT2D1 Homo sapiens Q8WV19
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

MST1 抗体

目录号 产品名 应用 反应物种
HY-P82623 MST1 Antibody (YA2368) WB, IHC-P, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]
Inflammatory Bowel Disease 12

IBD12
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100526 XMU-MP-1 Inhibitor 99.24% 否
HY-128206 I3MT-3 Inhibitor 99.98% 否
HY-151257 IHMT-MST1-58 Inhibitor 99.05% 否
HY-164595 IHMT-MST1-39 / 否
HY-P1790 Axltide / 否
HY-RS08729 MST1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08730 MST1R Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MST1 VGNC VGNC:81281
Felis catus MST1 VGNC VGNC:80630
Mus musculus MST1 MGD MGI:96080
Rattus norvegicus MST1 RGD RGD:3114
Others MST1 NCBI
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