TIGIT 蛋白, Mouse (HEK293, mFc)

TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TIGIT Protein, Mouse (HEK293, mFc) is 125 a.a., with molecular weight of ~39-52 KDa.

TIGIT 蛋白以其信号受体结合活性为特征，在 T 细胞激活的负调节上游发挥作用。该蛋白预计在细胞表面具有活性，与人 TIGIT（具有 Ig 和 ITIM 结构域的 T 细胞免疫受体）同源，与 T 细胞反应的调节相关。TIGIT 的表达存在偏差，在大肠、小肠和其他几种组织中观察到显着水平，强调了其在这些环境中免疫调节中的潜在作用。

Immobilized Recombinant Mouse CD155/PVR at 2.5 μg/mL (100 μL/well) can bind Biotinylated Recombinant Mouse TIGIT Protein. The ED₅₀ for this effect is 88.36 ng/mL.

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  Immobilized Recombinant Mouse CD155/PVR at 2.5 μg/mL (100 μL/well) can bind Biotinylated Recombinant Mouse TIGIT Protein. The ED₅₀ for this effect is 88.36 ng/mL.

Mouse

HEK293

C-mFc

NP_001139797 (A17-G141)

100043314  [NCBI]

AFLATGATAGTIDTKRNISAEEGGSVILQCHFSSDTAEVTQVDWKQQDQLLAIYSVDLGWHVASVFSDRVVPGPSLGLTFQSLTMNDTGEYFCTYHTYPGGIYKGRIFLKVQESSVAQFQTAPLG

Approximately 39-52 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.