UBAC1 蛋白, Human (GST)

The UBAC1 protein is a non-catalytic component of the KPC complex and contributes to polyubiquitination, targeting proteins such as CDKN1B and NFKB1. The KPC complex regulates the cell cycle by ubiquitinating and degrading CDKN1B during G1 phase. UBAC1 Protein, Human (GST) is the recombinant human-derived UBAC1 protein, expressed by E. coli , with N-GST labeled tag. The total length of UBAC1 Protein, Human (GST) is 405 a.a., with molecular weight of 72.3 kDa.

UBAC1 蛋白作为 KPC 复合体中的非催化成分，KPC 复合体是一种 E3 泛素-蛋白连接酶复合体，负责介导靶蛋白（包括 CDKN1B 和 NFKB1）的多泛素化。KPC 复合物在 G1 期催化多泛素化和随后蛋白酶体介导的 CDKN1B 降解，在细胞周期调节中发挥着至关重要的作用。此外，它通过 p105 前体的泛素化促进 NFKB1 的成熟，从而充当 NF-kappa-B 信号通路的关键调节因子。在 KPC 复合物中，UBAC1 充当接头，促进多泛素化靶蛋白（由 RNF123/KPC1 提供）转移至 26S 蛋白酶体。UBAC1 的参与强调了它对蛋白质修饰过程的贡献，特别是在蛋白质泛素化领域。

Human

E. coli

N-GST

Q9BSL1 (M1-T405)

10422  [NCBI]

MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKMADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTEIFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT

72.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.