1. Gene
  2. UBAC1 - UBA domain containing 1 Gene

UBAC1 - UBA domain containing 1 Gene

中文名称:含 UBA 域 1

种属: Homo sapiens

同用名: KPC2; GBDR1; UBADC1

基因 ID: 10422 | 基因类型: protein coding

关于 UBAC1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,932,969-135,961,373 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 32.5), testis (RPKM 24.1) and 25 other tissues.

功能概要

预测参与蛋白质泛素化。位于高尔基体;胞质溶胶;和质膜。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

UBAC1 基因产物(1)

mRNA Protein Name
NM_016172.3 NP_057256.2 ubiquitin-associated domain-containing protein 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
16227581 GOA
enables proteasome binding IDA
IDA: 通过直接分析推断
16227581 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein maturation IDA
IDA: 通过直接分析推断
25860612 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
16227581 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBAC1 蛋白结构

UBA

UBA: UBA/TS-N domain (192 - 228)

UBA

UBA: UBA/TS-N domain (290 - 325)

  • 0
  • 100
  • 200
  • 300
  • 405 a.a.
蛋白主名 其他名称

ubiquitin-associated domain-containing protein 1

E3 ubiquitin-protein ligase subunit KPC2

UBAC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBAC1 Q9BSL1 MCM10 Homo sapiens Q7L590-2
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 MCM10 Homo sapiens Q7L590-2
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 RNF123 Homo sapiens Q5XPI4
Anti Bait CoIP
17353931
种属内
UBAC1 Q9BSL1 RNF123 Homo sapiens Q5XPI4
Anti Tag CoIP
33961781
种属内
UBAC1 Q9BSL1 RNF123 Homo sapiens Q5XPI4
Anti Tag CoIP
28514442
种属内
UBAC1 Q9BSL1 CCDC138 Homo sapiens Q96M89-2
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 CCDC138 Homo sapiens Q96M89-2
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 POU6F2 Homo sapiens P78424
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 PLAAT2 Homo sapiens Q9NWW9
Validated Y2H
32296183
种属内
UBAC1 Q9BSL1 PLAAT2 Homo sapiens Q9NWW9
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 PLAAT2 Homo sapiens Q9NWW9
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 MGAT3 Homo sapiens Q09327
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 MGAT3 Homo sapiens Q09327
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 PSEN2 Homo sapiens P49810
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 PSEN2 Homo sapiens P49810
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 PSEN2 Homo sapiens P49810
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 ALS2 Homo sapiens A0A0S2Z5Q7
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 ALS2 Homo sapiens A0A0S2Z5Q7
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 ALS2 Homo sapiens A0A0S2Z5Q7
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 SPART Homo sapiens Q8N0X7
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 SPART Homo sapiens Q8N0X7
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 UBC Homo sapiens P0CG48
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 UBC Homo sapiens P0CG48
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 UBB Homo sapiens P0CG47
Anti Tag CoIP
28514442
种属内
UBAC1 Q9BSL1 UBB Homo sapiens P0CG47
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 UBB Homo sapiens P0CG47
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 UBB Homo sapiens P0CG47
Anti Tag CoIP
33961781
种属内
UBAC1 Q9BSL1 UCHL1 Homo sapiens P09936
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 UCHL1 Homo sapiens P09936
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 UCHL1 Homo sapiens P09936
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
种属内
UBAC1 Q9BSL1 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
25416956
种属内
UBAC1 Q9BSL1 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
种属内
UBAC1 Q9BSL1 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
种属内
UBAC1 Q9BSL1 PRPS1 Homo sapiens P60891
Y2H Array
32814053
种属内
UBAC1 Q9BSL1 TRIM2 Homo sapiens Q9C040
Validated Y2H
25416956
种属内
UBAC1 Q9BSL1 TRIM2 Homo sapiens Q9C040
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 TRIM2 Homo sapiens Q9C040
Y2H Array
25416956
种属内
UBAC1 Q9BSL1 TRIM2 Homo sapiens Q9C040
Y2H
21516116
种属内
UBAC1 Q9BSL1 TRIM2 Homo sapiens Q9C040
Y2H Prey Pooling
25416956
种属内
UBAC1 Q9BSL1 TRIM2 Homo sapiens Q9C040
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 TRIM2 Homo sapiens Q9C040
Validated Y2H
32296183
种属内
UBAC1 Q9BSL1 IGFBP6 Homo sapiens P24592
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 IGFBP6 Homo sapiens P24592
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
UBAC1 Q9BSL1 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属内
UBAC1 Q9BSL1 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBAC1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700392 UBAC1 Protein, Human (GST) Q9BSL1 (M1-T405) ≥95%

关联疾病

疾病名称 别名
Urinary Tract Infection

Urinary Tract Infections

Uti

Urinary Tract Infection Nos

Uti - [Urinary Tract Infection]

Uti Nos - [Urinary Tract Infection Nos]

Urosepsis Nos

E Coli Uti

E Coli Urinary Tract Infection

Escherichia Coli Uti

Pyelitis
Acute Pyelonephritis

Apn - [Acute Pyelonephritis]

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii

Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii

Granulomatous Disease, Chronic, Due To Ncf4 Deficiency

Chronic Granulomatous Disease 3, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 3

Autosomal Recessive Cytochrome B-Positive Cgd Type Iii

Cdg3

Chronic Granulomatous Disease Due To Ncf4 Deficiency

Cgd Autosomal Recessive Cytochrome B-Positive Type Iii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii

Granulomatous Disease Chronic Due To Ncf4 Deficiency

Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Blood Group, Globoside System

Globe Disease

GLOB

Blood Group System, Globoside

Parametritis

Pelvic Cellulitis

Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 9

CMS9

Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency

Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency

Endophthalmitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus UBAC1 MGD MGI:1920995
Macaca mulatta UBAC1 VGNC VGNC:79837
Canis familiaris UBAC1 VGNC VGNC:48042
Felis catus UBAC1 VGNC VGNC:66752
Rattus norvegicus UBAC1 RGD RGD:1359542
Bos taurus UBAC1 VGNC VGNC:36567
Others UBAC1 NCBI