1. Gene
  2. MGAT3 - beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Gene

MGAT3 - beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Gene

中文名称:beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

种属: Homo sapiens

同用名: GNT3; GNT-III

基因 ID: 4248 | 基因类型: protein coding

关于 MGAT3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,457,012-39,492,194 (from NCBI)

This gene has 3 transcripts (splice variants) and 209 orthologues. Broad expression in brain (RPKM 4.5), small intestine (RPKM 3.0) and 17 other tissues.

功能概要

据信有超过 100 种不同的糖基转移酶参与蛋白质结合和脂质结合的寡糖的合成。由该基因编码的酶将 GlcNAc 残基转移到 N-连接寡糖的三甘露糖核心的 β-连接甘露糖上,并产生二等分 GlcNAc。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供,2008 年 7 月]

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The Enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

MGAT3 基因产物(2)

mRNA Protein Name
NM_001098270.2 NP_001091740.1 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
NM_002409.5 NP_002400.3 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IMP
IMP: 通过突变表型推断
19403558 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein localization IMP
IMP: 通过突变表型推断
19403558 GOA
involved in regulation of cell migration IDA
IDA: 通过直接分析推断
26801611 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MGAT3 蛋白结构

Glyco_transf_17

Glyco_transf_17: Glycosyltransferase family 17 (164 - 504)

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  • 533 a.a.
蛋白主名 其他名称

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

GlcNAc-T III

MGAT3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MGAT3 Q09327 UBAC1 Homo sapiens Q9BSL1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hepatoblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MGAT3 RGD RGD:3084
Felis catus MGAT3 VGNC VGNC:96703
Bos taurus MGAT3 VGNC VGNC:96698
Mus musculus MGAT3 MGD MGI:104532
Canis familiaris MGAT3 VGNC VGNC:54526