2. PROTAC Autophagy
  3. Autophagy Ligands for E3 Ligase
  4. (S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc

(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc 

目录号: HY-161183
产品使用指南

摩尔计算器

(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc 是 E3 连接酶配体与连接子的缀合物 (E3 Ligase Ligand-Linker Conjugates)，由 Thalidomide (HY-14658) 和对应 Linker 构成。(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc 可作为 Cereblon 配体募集 CRBN 蛋白，并作为关键中间体进行完整 PROTACs 分子合成。

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(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc Chemical Structure

(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc Chemical Structure

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(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc 相关抗体

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查看 Ligands for E3 Ligase 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]
分子量

598.69

Formula

C31H42N4O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-boc 相关分类

  • 摩尔计算器

  • 稀释计算器

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

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Keywords:

(S)-Thalidomide-O-(1S,3r)-C4H4-N(Me)-Pip-C2-O-C-bocAutophagyLigands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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