1. Metabolic Enzyme/Protease Apoptosis
  2. Phosphatase MDM-2/p53 Apoptosis
  3. SPI-001

SPI-001 是一种 PPM1D 特异性抑制剂 (IC50=0.48 μM),具有抗癌活性。SPI-001 抑制了 PPM1D 过表达的人类乳腺癌细胞中的 PPM1D 磷酸酶活性并增加了 p53 的磷酸化。此外,SPI-001 通过诱导细胞凋亡 (apoptosis) 来抑制细胞增殖。

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SPI-001 Chemical Structure

SPI-001 Chemical Structure

CAS No. : 1220996-46-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SPI-001 is a PPM1D-specific inhibitor (IC50=0.48 μM) with anticancer activity. SPI-001 inhibits PPM1D phosphatase activity and increases p53 phosphorylation in PPM1D-overexpressing human breast cancer cells. In addition, SPI-001 inhibits cell proliferation by inducing apoptosis[1].

分子量

540.97

Formula

C30H60O4Si2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SPI-001
目录号:
HY-164537
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