Terodiline  (Synonyms: 特罗地林)

Terodiline, an antispasmodic agent, blocks hERG current with the IC₅₀ of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence^[1][2].

mAChR^[1]
Ca²⁺ channel^[1]

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID₅₀= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED₅₀=59 mg/kg)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

281.44

C₂₀H₂₇N

15793-40-5

特罗地林

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ruth L Martin, et al. In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience. J Cardiovasc Pharmacol. 2006 Nov;48(5):199-206.  [Content Brief]

  [2]. H D Langtry, et al. Terodiline. A review of its pharmacological properties, and therapeutic use in the treatment of urinary incontinence. Drugs. 1990 Nov;40(5):748-61.   [Content Brief]