2. Anti-infection Autophagy
  3. Bacterial Autophagy Antibiotic
  4. Tigecycline mesylate

Tigecycline mesylate  (Synonyms: 甲磺酸替加环素; GAR-936 mesylate)

目录号: HY-B0117B
产品使用指南

摩尔计算器

Tigecycline mesylate (GAR-936 mesylate) 是一种广谱的甘氨酰环素抗生素。Tigecycline 对 E. coli (MG1655 菌株) 的平均抑制浓度 (MIC) 约为 125 ng/ mL。对 Acinetobacter baumannii (A. baumannii) 的 MIC50 和 MIC90 分别为 1 和 2 mg/L。

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Tigecycline mesylate Chemical Structure

Tigecycline mesylate Chemical Structure

CAS No. : 1135871-27-0

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Tigecycline mesylate 的其他形式现货产品:

Other Forms of Tigecycline mesylate:

Tigecycline mesylate 相关抗体

Top Publications Citing Use of Products

    Tigecycline mesylate purchased from MCE. Usage Cited in: Microbiol Spectr. 2022 Dec 8;e0323822.  [Abstract]

    The MIC distributions of Tigecycline against 43 M. fortuitum isolates (incubate for 24 h). The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tigecycline mesylate (GAR-936 mesylate) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL[1]. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively[2].

    IC50 & Target

    Mean MIC: 125 ng/mL (E. coli)[1]
    MIC50: 1 mg/mL (A. baumannii)[2]
    MIC90: 2 mg/mL (A. baumannii)[2]
    体外研究
    (In Vitro)

    Tigecycline (0.63-30 µM, preincubated for 4 days, treated for 72 h) inhibits AML2 cells and HL-60 cells with IC50s of 4.72±0.54 and 3.06±0.85 μM (freshly prepared). Tigecycline inhibits AML2 cells and HL-60 cells with IC50s of 5.64±0.55 and 4.27±0.45 μM (1 day preincubation). Tigecycline inhibits AML2 cells and HL-60 cells with IC50s of 5.02±0.60 and 4.39±0.44 μM (2 day preincubation). Tigecycline inhibits AML2 cells and HL-60 cells with IC50s of 4.09±0.41 and 3.95±0.39 μM (3 day preincubation). After a 4 day preincubation of Tigecycline in saline, Tigecycline lost its ability to kill TEX human leukemia cells (from IC50~5 µM when freshly prepared to IC50>50 µM after 4 days preincubation) as measured by CellTiter Flour assay[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Tigecycline mesylate 相关抗体:

    Cell Viability Assay[1]

    Cell Line: Human leukemic OCI-AML2, HL-60 (ATCC) and TEX cell lines
    Concentration: 0.63-30 µM
    Incubation Time: Preincubated for 4 days, treated for 72 hours
    Result: Inhibited AML2 cells and HL-60 cells with IC50s of 4.72±0.54 and 3.06±0.85 μM (freshly prepared).
    体内研究
    (In Vivo)

    Tigecycline (50 mg/kg; intraperitoneal injection; twice a day; for 11 days) reduces tumor volume and weight in NOD/SCID mice[1].
    The peak plasma concentration (Cmax), the terminal half-life (t1/2), area under the plasma concentration-time curve (AUC), clearance (CL) and volume of distribution (Vz) are 22.8μg/mL, 108.9 min, 1912.2min*μg/mL, 26.1 mL/min/kg, 4109.4 mL/kg for Tigecycline in saline, respectively. The peak plasma concentration (Cmax), the terminal half-life (t1/2), area under the plasma concentration-time curve (AUC), clearance (CL) and volume of distribution (Vz) are15.7μg/mL, 110.3 min, 2036.5 min*μg/mL, 24.6 mL/min/kg, 3906.2 mL/kg for Tigecycline in formulation (60 mg/mL pyruvate, 3 mg/mL ascorbic acid, pH 7 in saline) , respectively[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: NOD/SCID mice with OCI-AML2 acute myeloid leukemia (AML) xenograft model[1]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection; twice a day; for 11 days
    Result: Reduced tumor volume and weight.
    Animal Model: NOD/SCID mice[1]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection; 360 minutes
    Result: The peak plasma concentration (Cmax), the terminal half-life (t1/2), area under the plasma concentration-time curve (AUC), clearance (CL) and volume of distribution (Vz) are 22.8 μg/mL, 108.9 min, 1912.2 min*μg/mL, 26.1 mL/min/kg, 4109.4 mL/kg, respectively.
    Clinical Trial
    分子量

    681.75

    Formula

    C30H43N5O11S
    CAS 号
    中文名称

    甲磺酸替加环素
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Tigecycline mesylate 相关分类

    • 摩尔计算器

    • 稀释计算器

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    The dilution calculator equation

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    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tigecycline1135871-27-0GAR-936甲磺酸替加环素GAR936GAR 936BacterialAutophagyAntibioticInhibitorinhibitorinhibit

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