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  4. Trypanothione synthetase-IN-2

Trypanothione synthetase-IN-2 

目录号: HY-151150
产品使用指南

摩尔计算器

Trypanothione synthetase-IN-2 (Compound 3) 是一种竞争性的婴儿利什曼虫锥虫胱甘肽合成酶 (TryS) 抑制剂，当三胺亚精胺作为多胺 S 时，IC50 为 5.4 μM。

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Trypanothione synthetase-IN-2 Chemical Structure

Trypanothione synthetase-IN-2 Chemical Structure

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Trypanothione synthetase-IN-2 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 5.4 μM when triamine spermidine is as polyamine S[1].

IC50 & Target

Leishmania

 

体外研究
(In Vitro)

Trypanothione synthetase-IN-2 (Compound 3) (0-75 μM; 24 or 72 h) shows leishmanicidal activity without cytotoxicity[1].
Trypanothione synthetase-IN-2 displays a classical competitive mechanism of inhibition against the polyamine substrates[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Trypanothione synthetase-IN-2 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: L. infantum, HepG2
Concentration: 0-75 μM
Incubation Time: 24 h (L. infantum axenic amastigotes) or 72 h
Result: Showed leishmanicidal activity with EC50s of 7.3 ± 0.5 μM and 17.9 ± 0.4 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC50 of >75 μM against HepG2 cells.
分子量

836.03

Formula

C41H69N7O11
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Trypanothione synthetase-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypanothione synthetase-IN-2ParasiteleishmanicidalLeishmania infantumtrypanothione synthetaseTrySInhibitorinhibitorinhibit

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