2. Anti-infection
  3. SARS-CoV
  4. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 

目录号: HY-N11902
产品使用指南

摩尔计算器

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 是一种有效的 N 蛋白抑制剂可以从 Curcuma kwangsiensis 中分离得到。1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 对 HCoV-OC43 和 SARS-CoV-2 表现出优异的抗病毒活性，EC50 值分别为 0.16 μM 和 0.17 μM。

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1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one Chemical Structure

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one Chemical Structure

CAS No. : 149732-52-5

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规格 价格 是否有货 数量
1 mg ￥4320
1 - 2 周
5 mg   询价  
10 mg   询价  

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1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent nucleocapsid (N) protein inhibitor can be isolated from Curcuma kwangsiensis. 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one exhibits excellent antiviral activity against HCoV-OC43 and SARS-CoV-2,with EC50 values of 0.16 μM and 0.17 μM, respectively[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
KB IC50
5.75 μM
Compound: 4
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
[PMID: 24857542]
PC-12 ED50
> 50 μg/mL
Compound: 8
Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
[PMID: 12350137]
PC-12 ED50
> 50 μg/mL
Compound: 8
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay
[PMID: 12350137]
Vero IC50
9.65 μM
Compound: 4
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
[PMID: 24857542]
分子量

292.33

Formula

C19H16O3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 相关分类

  • 摩尔计算器

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质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one149732-52-5SARS-CoVSARS coronavirusAntiviral activityInhibitorinhibitorinhibit

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