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  4. 17β-HSD1-IN-2

17β-HSD1-IN-2 (PBRM) 是一种非雌激素和类固醇共价不可逆的 17β-羟基类固醇脱氢酶 1 型 (17β-HSD1) 抑制剂 (Ki=368 nM)。17β-HSD1-IN-2 可用于雌激素依赖性疾病的研究。

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17β-HSD1-IN-2 Chemical Structure

17β-HSD1-IN-2 Chemical Structure

CAS No. : 1318265-18-7

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17β-HSD1-IN-2 相关抗体

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  • 生物活性

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生物活性

17β-HSD1-IN-2 (PBRM) is a non-estrogenic and steroidal covalent irreversible inhibitor of 17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) (Ki=368 nM). 17β-HSD1-IN-2 can be used for the research of estrogen-dependent disorders[1].

IC50 & Target

17β-HSD1[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
T47D IC50
68 nM
Compound: 23b
Inhibition of 17-beta HSD1 in human T47D cells assessed as transformation of [14C]E1 to [14C]E2 after 24 hrs by thin layer chromatography
Inhibition of 17-beta HSD1 in human T47D cells assessed as transformation of [14C]E1 to [14C]E2 after 24 hrs by thin layer chromatography
[PMID: 24328103]
T47D IC50
68 nM
Compound: 5
Inhibition of 17beta-HSD1 in human T47D cells assessed as decrease in transformation of [14C]estrone to [14C]-estradiol after 24 hrs by thin layer chromatography
Inhibition of 17beta-HSD1 in human T47D cells assessed as decrease in transformation of [14C]estrone to [14C]-estradiol after 24 hrs by thin layer chromatography
[PMID: 21927646]
分子量

496.48

Formula

C28H34BrNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

17β-HSD1-IN-2 相关分类

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Keywords:

17β-HSD1-IN-21318265-18-7Othersnon-estrogenicsteroidal covalentestrogen-dependentInhibitorinhibitorinhibit

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