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  3. Fluorescent Dye
  4. 8pyDTZ

8pyDTZ 是一种吡啶基二苯基叔嗪 (DTZ) 类似物，也是 一种 LumiLuc 荧光素酶的 ATP 非依赖性吡啶基底物。8pyDTZ 具有出色的生物相容性和体内敏感性，可用于生物体内发光成像。

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8pyDTZ Chemical Structure

8pyDTZ Chemical Structure

CAS No. : 2351898-91-2

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规格 价格 是否有货 数量
1 mg ￥2045
In-stock
5 mg ￥4500
In-stock
10 mg 现货 询价
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Customer Review

8pyDTZ 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission. 8pyDTZ has excellent biocompatibility and superior in vivo sensitivity. 8pyDTZ can be used for in vivo luminescence imaging[1].

体外研究
(In Vitro)

Compared to DTZ, 8pyDTZ (compounds 3c) is able to emit red-shifted chemiluminescence or bioluminescence. 8pyDTZ shows the most red-shifted emission and red-shifted photons can penetrate through tissue better[1].
LumiLuc-8pyDTZ in human embryonic kidney (HEK) 293T cells transiently expressing the luciferase is evaluated. The LumiLuc-8pyDTZ pair produces ∼3-5-fold more bioluminescence than teLuc-8pyDTZ. To compare far-red emission intensities of bioluminescent reporters, HEK 293T cells in the presence of a 600-700 nm band pass filter are imaged. At substrate concentrations from 6.25 to 100 μM, LumiLuc-8pyDTZ consistently produces 1.6-3.9-fold higher photon flux than teLuc-DTZ. No ATP perturbation is observed from 8pyDTZ-treated, LumiLucexpressing cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

8pyDTZ 相关抗体:
体内研究
(In Vivo)

LumiLuc-8pyDTZ pair is compared with several benchmark reporters in a tumor xenograft mouse model. LumiLuc-8pyDTZ shows high sensitivity and does not need organic cosolvents for in vivo administration. LumiScarlet-8pyDTZ is comparable to Akaluc-AkaLumine, the brightest ATP-dependent luciferase-luciferin pair, for detecting cells in deep tissues of mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

378.43

Formula

C24H18N4O
CAS 号
性状

固体

颜色

Light brown to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

EtOH + HCl 中的溶解度 : 2 mg/mL (5.28 mM; ultrasonic and adjust pH to 2 with 1M HCl; DMSO can inactivate 8pyDTZ's activity)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble; DMSO can inactivate 8pyDTZ's activity)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6425 mL 13.2125 mL 26.4250 mL
5 mM 0.5285 mL 2.6425 mL 5.2850 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (201 KB) HNMR (261 KB)

产品使用指南 (1538 KB)
参考文献

8pyDTZ 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
EtOH + HCl 1 mM 2.6425 mL 13.2125 mL 26.4250 mL 66.0624 mL
5 mM 0.5285 mL 2.6425 mL 5.2850 mL 13.2125 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8pyDTZ2351898-91-2Fluorescent DyePyridylDTZLumiLucluciferaseATP-independentwatersolubilityluminescenceInhibitorinhibitorinhibit

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目录号：
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