2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. A-889425

A-889425 是一种具有口服活性选择性 TRPV1 受体拮抗剂，IC50 值为 335 nM（大鼠）和 34 nM（人）。A-889425 对中枢神经系统有良好的渗透作用，可减少机械性异常痛和脊髓神经元对 Complete Freund's adjuvant (HY-153808) 炎症大鼠后爪机械刺激的反应。

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A-889425 Chemical Structure

A-889425 Chemical Structure

CAS No. : 1072921-02-8

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A-889425 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-889425 is an oral active selective TRPV1 receptor antagonist with the with an IC50 of 335 nM (rat) and 34 nM (human). A-889425 has good penetration into the CNS and reduces mechanical allodynia and spinal neuron responses to mechanical stimulation of Complete Freund's adjuvant (HY-153808)-inflamed rat hind paws[1][2].

分子量

425.42

Formula

C19H18F3N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-889425 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-8894251072921-02-8A889425A 889425TRP ChannelTransient receptor potential channelsComplete Freund's adjuvant (HY-153808)-inflamed rat hind pawsInhibitorinhibitorinhibit

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产品名称：
A-889425
目录号：
HY-133166
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