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Antiproliferative agent-15 

目录号: HY-W278944 纯度: 99.18%
COA 产品使用指南

摩尔计算器

Antiproliferative agent-15 是一种抗癌剂， 对人结肠癌细胞系 (HCT116 和 HCT15)、脑癌细胞系 (LN-229 和 GBM-10) 显示出抗增殖活性。

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Antiproliferative agent-15 Chemical Structure

Antiproliferative agent-15 Chemical Structure

CAS No. : 19819-18-2

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5 mg ￥3010
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10 mg ￥4480
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Antiproliferative agent-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
> 100 μM
Compound: 6a
Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay
[PMID: 28759878]
CHO IC50
> 100 μM
Compound: 6a
Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay
Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay
[PMID: 28759878]
HCT-116 IC50
> 10 μM
Compound: 4e
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay
[PMID: 32153186]
HCT-116 IC50
8.3 μM
Compound: 6a
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
[PMID: 28759878]
HCT-15 IC50
4.8 μM
Compound: 6a
Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay
Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay
[PMID: 28759878]
LN-229 IC50
18.3 μM
Compound: 6a
Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay
Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay
[PMID: 28759878]
MCF7 IC50
> 30 μM
Compound: 6c
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 29172540]
MDA-MB-231 IC50
> 30 μM
Compound: 6c
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay
[PMID: 29172540]
体外研究
(In Vitro)

Antiproliferative agent-15 (compound 6a) shows antiproliferative activity against human colon (HCT116 and HCT15), brain (LN-229 and GBM-10) cancer cell lines, with IC50 values of 8.3 μM, 4.8 μM, 18.3 μM, and 12 μM, respectively. However, Antiproliferative agent-15 has no active against ovarian (A2780) cancer cell lines and normal cell line (CHO)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-15 相关抗体:
分子量

282.36

Formula

C16H14N2OS
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 1.67 mg/mL (5.91 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5416 mL 17.7079 mL 35.4158 mL
5 mM 0.7083 mL 3.5416 mL 7.0832 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Antiproliferative agent-15 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5416 mL 17.7079 mL 35.4158 mL 88.5395 mL
5 mM 0.7083 mL 3.5416 mL 7.0832 mL 17.7079 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-1519819-18-2Antiproliferative agent15Antiproliferative agent 15Othersanticancer agentcolon and brain cancer cell linesInhibitorinhibitorinhibit

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