2. Neuronal Signaling
  3. Beta-secretase
  4. BACE1-IN-13

BACE1-IN-13 (Compound 36) 是一种 BACE1 抑制剂，具有口服活性，IC50 值为 2.9 nM。BACE1-IN-13 在 hAβ42 细胞中非常有效 (IC50 = 1.3 nM)。BACE1-IN-13 具有心血管安全性，并能在小鼠和狗动物模型中引起 Aβ42 持续减少。

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BACE1-IN-13 Chemical Structure

BACE1-IN-13 Chemical Structure

CAS No. : 1397683-26-9

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BACE1-IN-13 相关抗体

Top Publications Citing Use of Products

查看 Beta-secretase 亚型特异性产品:

查看所有亚型
BACE1 BACE2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BACE1-IN-13 (Compound 36) is an orally active BACE1 inhibitor with an IC50 value of 2.9 nM. BACE1-IN-13 is highly potent in hAβ42 cell (IC50 = 1.3 nM). BACE1-IN-13 has cardiovascularly safty and elicits sustained Aβ42 reduction in mouse and dog animal models[1].

IC50 & Target

IC50: 1.3 nM (hAβ42 cell)[1].
分子量

420.40

Formula

C20H17FN8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BACE1-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BACE1-IN-131397683-26-9Beta-secretaseBACEβ-SecretaseBACE1hAβ42cardiovascularanimal modelInhibitorinhibitorinhibit

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产品名称：
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