2. Apoptosis
  3. Apoptosis
  4. Berubicin hydrochloride

Berubicin hydrochloride  (Synonyms: RTA 744; WP 744; WP 769 hydrochloride)

目录号: HY-14942A 纯度: 95.08%
COA 产品使用指南

摩尔计算器

Berubicin hydrochloride (RTA 744) 是一种阿霉素 (Doxorubicin，HY-15142A) 类似物。Berubicin hydrochloride通过激活促凋亡介质在 NB 细胞中触发凋亡 (Apoptosis) 和细胞杀伤。Berubicin hydrochloride 具有促凋亡和抗白血病活性。Berubicin hydrochloride 可用于癌症研究。

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Berubicin hydrochloride Chemical Structure

Berubicin hydrochloride Chemical Structure

CAS No. : 293736-67-1

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1 mg ￥2450
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Other Forms of Berubicin hydrochloride:

Berubicin hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Berubicin hydrochloride (RTA 744) is a Doxorubicin (HY-15142A) analogue. Berubicin hydrochloride triggers apoptosis and cell killing in NB cells by activating proapoptotic mediators. Berubicin hydrochloride has proapoptotic and anti-leukemia activities. Berubicin hydrochloride can be used for cancer research[1][2][3].

体外研究
(In Vitro)

Berubicin hydrochloride 抑制 K562 细胞的活性，IC50 值为 0.18 mg/mL[1]。
Berubicin hydrochloride (0-100 µM；24 h) 抑制 KBM-5 细胞吸收胸腺嘧啶[2]。
Berubicin hydrochloride (1 µM；15 min) 在 KBM-5 细胞中通过 NF-κB 的 p50 和 p65 亚基激活 NF-κB[2]。
Berubicin hydrochloride (0-100 µM；72 h) 以剂量依赖性方式抑制 Jurkat 和 RIP 缺失的 Jurkat 细胞增值[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Berubicin hydrochloride 相关抗体:

Cell Viability Assay[2]

Cell Line: KBM-5 cells.
Concentration: 0, 0.1, 1, 10 and 100 µM.
Incubation Time: 24 h.
Result: Inhibited cell viability with dose-dependent manner.

Western Blot Analysis[2]

Cell Line: KBM-5 cells.
Concentration: 0, 0.1, 1 and 10 µM.
Incubation Time: 4 h.
Result: Increased NF-κB expression with time and dose dependent manner.

Cell Viability Assay[3]

Cell Line: SH-SY5Y cells.
Concentration: 0.1, 1 and 10 µM.
Incubation Time: 0, 1, 2, 3, 4 and 5 d.
Result: Inhibited cell viability with dose-dependent manner.

Apoptosis Analysis[3]

Cell Line: SH-SY5Y cells.
Concentration: 50, 500 and 2000 nM.
Incubation Time: 48 h.
Result: Promoted cell apoptosis.

Western Blot Analysis[3]

Cell Line: SH-SY5Y cells.
Concentration: 0, 0.1, 1.0 or 10 µM.
Incubation Time: 0, 0.5, 1, 2, 4, 6, 8, 12 or 24 h.
Result: Activated Casp 3 and Casp 9.
Increased p53 and NF-κB expression.
Reduced IκBα expression.
Clinical Trial
分子量

670.10

Formula

C34H36ClNO11
CAS 号
性状

固体

颜色

Brown to red

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Berubicin hydrochloride 相关分类

  • 摩尔计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Berubicin293736-67-1RTA 744 WP 744WP 769RTA744RTA-744WP744WP 744WP-744WP769WP-769ApoptosisSH-SY5Y cellsKBM-5 cellsNF-κBJurkat cellsCasp 3Casp 9p53Inhibitorinhibitorinhibit

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