BLK-IN-2

目录号: HY-144288 纯度: 98.72%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

BLK-IN-2 (compound 25) 是一种有效的，选择性和不可逆的 B-淋巴酪氨酸激酶 (BLK) 抑制剂，IC₅₀ 值为 5.9 nM。BLK-IN-2 还可以抑制 BTK (IC₅₀=202.0 nM)。BLK-IN-2 对几种淋巴瘤细胞显示出有效的抗增殖活性。

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BLK-IN-2 Chemical Structure

CAS No. : 2694871-86-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥6770	In-stock
1 mg	￥2045	In-stock
5 mg	￥4500	In-stock
10 mg	现货	询价
50 mg		询价
100 mg		询价

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生物活性
纯度 & 产品资料
参考文献

生物活性

BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC₅₀ of 5.9 nM. BLK-IN-2 also inhibits BTK (IC₅₀=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells^[1].

IC₅₀ & Target

IC50: 5.9 nM (BLK)^[1], 202.0 nM (BTK)^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-375	GI₅₀	> 30 μM Compound: 25	Antiproliferative activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human A-375 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
A-431	GI₅₀	> 30 μM Compound: 25	Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
A549	GI₅₀	> 30 μM Compound: 25	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
DOHH-2	GI₅₀	0.016 μM Compound: 25	Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human DOHH-2 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
HBL1	GI₅₀	1.34 μM Compound: 25	Antiproliferative activity against human HBL1 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human HBL1 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
HCT-116	GI₅₀	8.1 μM Compound: 25	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
HEK293	GI₅₀	> 30 μM Compound: 25	Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against HEK293 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
Jurkat	GI₅₀	10.9 μM Compound: 25	Antiproliferative activity against human Jurkat cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human Jurkat cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
MDA-MB-453	GI₅₀	> 30 μM Compound: 25	Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human MDA-MB-453 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
MOLT-4	GI₅₀	18.8 μM Compound: 25	Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
OCI-Ly7	GI₅₀	0.02 μM Compound: 25	Antiproliferative activity against human OCILY7 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human OCILY7 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
PBMC	GI₅₀	> 30 μM Compound: 25	Antiproliferative activity against human PBMC cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human PBMC cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
Pfeiffer	GI₅₀	2.18 μM Compound: 25	Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
SU-DHL10	GI₅₀	0.56 μM Compound: 25	Antiproliferative activity against human SU-DHL-10 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human SU-DHL-10 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
SU-DHL-6	GI₅₀	0.13 μM Compound: 25	Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]
TMD8	GI₅₀	0.064 μM Compound: 25	Antiproliferative activity against human TMD8 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay Antiproliferative activity against human TMD8 cells assessed as cell growth inhibition incubated for 72 hrs by celltiter-glo luminescent cell viability assay	[PMID: 34952433]

分子量

683.80

Formula

C₃₉H₄₁N₉O₃

CAS 号

2694871-86-6

性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 125 mg/mL (182.80 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4624 mL	7.3121 mL	14.6242 mL
5 mM	0.2925 mL	1.4624 mL	2.9248 mL
10 mM	0.1462 mL	0.7312 mL	1.4624 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.72%

选择批次：

Data Sheet (594 KB) SDS (251 KB)

COA (258 KB) HNMR (327 KB) LCMS (267 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Fu T, et, al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK). Eur J Med Chem. 2022 Feb 5;229:114051. [Content Brief]

BLK-IN-2 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4624 mL	7.3121 mL	14.6242 mL	36.5604 mL
	5 mM	0.2925 mL	1.4624 mL	2.9248 mL	7.3121 mL
	10 mM	0.1462 mL	0.7312 mL	1.4624 mL	3.6560 mL
	15 mM	0.0975 mL	0.4875 mL	0.9749 mL	2.4374 mL
	20 mM	0.0731 mL	0.3656 mL	0.7312 mL	1.8280 mL
	25 mM	0.0585 mL	0.2925 mL	0.5850 mL	1.4624 mL
	30 mM	0.0487 mL	0.2437 mL	0.4875 mL	1.2187 mL
	40 mM	0.0366 mL	0.1828 mL	0.3656 mL	0.9140 mL
	50 mM	0.0292 mL	0.1462 mL	0.2925 mL	0.7312 mL
	60 mM	0.0244 mL	0.1219 mL	0.2437 mL	0.6093 mL
	80 mM	0.0183 mL	0.0914 mL	0.1828 mL	0.4570 mL
	100 mM	0.0146 mL	0.0731 mL	0.1462 mL	0.3656 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLK-IN-22694871-86-6BtkBruton tyrosine kinaseB-Lymphoid tyrosine kinaseBLKBTKlymphomaInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BLK-IN-2

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