2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. BPDA2

BPDA2 是一种高选择性和竞争性活性位点 SHP2 抑制剂，对 SHP2、SHP1、SHP1B 的 IC50 分别为 92.0 nM、33.39 μM、40.71 μM。DBDA2 下调促有丝分裂、细胞存活信号和 RTK 表达。BPDA2 抑制 SHP2 介导的信号转导和乳腺癌细胞表型。

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BPDA2 Chemical Structure

BPDA2 Chemical Structure

CAS No. : 2907659-86-1

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BPDA2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes[1].

体外研究
(In Vitro)

BPDA2 (0.2-3.2 μM) 以浓度依赖性方式抑制 Akt 和 ERK1/2 的基础激活[1]。
BPDA2 (0.25-4.0 μM; 持续 10 天) 以浓度依赖性方式抑制乳腺癌细胞的贴壁非依赖性生长和癌症干细胞特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BPDA2 相关抗体:

Western Blot Analysis[1]

Cell Line: JIMT-1, MDA-MB468 cell
Concentration: 0.2, 0.4, 0.8, 1.6, 3.2 μM
Incubation Time:
Result: Inhibited basal activation of Akt and ERK1/2 in a concentration dependent manner.
分子量

398.49

Formula

C24H30O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BPDA2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPDA22907659-86-1BPDA 2BPDA-2SHP2Src homology phosphatase 2PTPN11CompetitiveSHP1SHP1BmitogenicRTKbreast cancerJIMT-1MDA-MB468Inhibitorinhibitorinhibit

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