2. NF-κB Apoptosis
  3. Keap1-Nrf2 Apoptosis
  4. CDDO-TFEA

CDDO-TFEA  (Synonyms: CDDO-Trifluoethyl amide; RTA 404; TP-500)

目录号: HY-130495
产品使用指南

摩尔计算器

CDDO-TFEA (RTA 404; TP-500) 是 CDDO 的三氟乙酰胺衍生物，具有增强的穿过血脑屏障的能力。CDDO 是一种 Nrf2 激活剂，可抑制增殖并诱导各种癌细胞分化和凋亡。CDDO-TFEA 可以增强各种神经退行性疾病模型中的 Nrf2 表达和信号传导，包括模拟多发性硬化症、肌萎缩侧索硬化症和亨廷顿氏病的模型。CDDO-TFEA 诱导尤文氏肉瘤和神经母细胞瘤细胞系凋亡，阻止集落形成，IC50 值范围为 85-170 nM。

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CDDO-TFEA Chemical Structure

CDDO-TFEA Chemical Structure

CAS No. : 932730-52-4

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规格 价格 是否有货 数量
1 mg ￥1458
3 - 4 周
5 mg ￥5832
3 - 4 周
10 mg   询价  
50 mg   询价  

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CDDO-TFEA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDDO-TFEA (RTA 404; TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging from 85-170 nM.

分子量

572.70

Formula

C33H43F3N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDDO-TFEA 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

CDDO-TFEA932730-52-4CDDO-Trifluoethyl amide RTA 404 TP-500RTA404RTA 404RTA-404TP500TP 500TP-500Keap1-Nrf2ApoptosisInhibitorinhibitorinhibit

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