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  4. Chaparrinone

Chaparrinone 是一种苦木素类化合物，可以从 Eurycoma Harmandiana 的根中分离出来。 Chaparrinone 对 Plasmodium falciparum 和 P-388 细胞具有抗疟和细胞毒活性 (IC50 分别为 0.037 和 0.34 μg/mL)。

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Chaparrinone Chemical Structure

Chaparrinone Chemical Structure

CAS No. : 22611-34-3

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规格 价格 是否有货 数量
1 mg ￥4160
1 - 2 周
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Chaparrinone 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC50: 0.037 and 0.34 μg/mL respectively)[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-549 IC50
0.8 μg/mL
Compound: chaparrinone
Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay
Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay
[PMID: 8984156]
Hep 3B2 IC50
2.17 μM
Compound: 4
Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay
[PMID: 23290052]
HepG2 IC50
> 50 μM
Compound: 4
Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay
Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay
[PMID: 23290052]
HepG2 IC50
1.2 μM
Compound: 4
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 23290052]
HL-60 IC50
1.2 μM
Compound: 26
Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter
Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter
[PMID: 11754601]
HL-60 EC50
2.4 μM
Compound: 26
Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay
Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay
[PMID: 11754601]
HL-60 IC50
5 μM
Compound: 26
Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay
Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay
[PMID: 11754601]
K562 IC50
1.8 μg/mL
Compound: chaparrinone
Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay
Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay
[PMID: 8984156]
KB ED50
0.025 μg/mL
Compound: 2, NSC-288754
Cytotoxicity against human KB cells by NCI method
Cytotoxicity against human KB cells by NCI method
[PMID: 6875576]
KB IC50
1.2 μg/mL
Compound: chaparrinone
Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay
Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay
[PMID: 8984156]
P388 IC50
0.92 μg/mL
Compound: 6
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
[PMID: 9644063]
SK-OV-3 IC50
0.5 μg/mL
Compound: chaparrinone
Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay
Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay
[PMID: 8984156]
Vero IC50
1.5 μg/mL
Compound: chaparrinone
Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay
Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay
[PMID: 8984156]
分子量

378.42

Formula

C20H26O7
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chaparrinone 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chaparrinone22611-34-3ParasiteantimalarialcytotoxicquassinoidInhibitorinhibitorinhibit

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