2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. iGluR mGluR
  4. cis-ACPD

cis-ACPD 是一种有效的 NMDA 受体激动剂，IC50 值为 3.3 μM。同时也是一种选择性的 group II mGluR 激动剂，对 mGluR2 和 mGluR4 的 EC50 值分别为 13 μM 和 50 μM。

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cis-ACPD Chemical Structure

cis-ACPD Chemical Structure

CAS No. : 477331-06-9

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Other Forms of cis-ACPD:

cis-ACPD 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].

IC50 & Target[1][2]

NMDA Receptor

3.3 μM (IC50)

mGluR2

13 μM (EC50)

mGluR4

50 μM (EC50)

体外研究
(In Vitro)

cis-ACPD is a selective group II mGluR agonist, with EC50s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively[2].
cis-ACPD (1-1000 µM; 60 min) stimulates hydrolysis of 3H-phosphoinositide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

cis-ACPD 相关抗体:
体内研究
(In Vivo)

cis-ACPD (1-1000 mg/kg; i.p.) produces dose-related convulsions in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

173.17

Formula

C7H11NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

cis-ACPD 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-ACPD477331-06-9iGluRmGluRIonotropic glutamate receptorsMetabotropic glutamate receptorsNMDAreceptorgroupIImGluR2mGluR4convulsionsInhibitorinhibitorinhibit

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